1jux

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[[Image:1jux.gif|left|200px]]<br /><applet load="1jux" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1jux.gif|left|200px]]
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caption="1jux, resolution 1.6&Aring;" />
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'''1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side'''<br />
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{{Structure
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|PDB= 1jux |SIZE=350|CAPTION= <scene name='initialview01'>1jux</scene>, resolution 1.6&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=DMY:DISTAMYCIN A'>DMY</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1JUX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=DMY:'>DMY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUX OCA].
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1JUX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUX OCA].
==Reference==
==Reference==
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Structure of d(ITITACAC) complexed with distamycin at 1.6 A resolution., Deng J, Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2342-4. Epub 2003, Nov 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14646114 14646114]
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Structure of d(ITITACAC) complexed with distamycin at 1.6 A resolution., Deng J, Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2342-4. Epub 2003, Nov 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14646114 14646114]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Deng, J.]]
[[Category: Deng, J.]]
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[[Category: side-by-side]]
[[Category: side-by-side]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:27:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:08:49 2008''

Revision as of 10:08, 20 March 2008

Image:1jux.gif


PDB ID 1jux

Drag the structure with the mouse to rotate
, resolution 1.6Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side


Overview

The crystal structure of the DNA octamer d(ITITACAC)(2) complexed with distamycin has been determined at 1.6 A resolution and refined to a final R(work) and R(free) of 17.0 and 20.7%, respectively. Two molecules of distamycin bind to the DNA duplex in an antiparallel side-by-side fashion. Each drug molecule covers five base pairs of the DNA duplex, with its amide groups hydrogen-bonding to bases in the proximal DNA strand. These two antiparallel drug molecules are stacked together with the pyrrole rings of one molecule stacking against the amide groups of the other. The present structure emphasizes the features of alternating DNA octamers in interaction with distamycin.

About this Structure

1JUX is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Structure of d(ITITACAC) complexed with distamycin at 1.6 A resolution., Deng J, Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2342-4. Epub 2003, Nov 27. PMID:14646114

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