1jv2

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[[Image:1jv2.gif|left|200px]]<br /><applet load="1jv2" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1jv2.gif|left|200px]]
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caption="1jv2, resolution 3.1&Aring;" />
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'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3'''<br />
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{{Structure
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|PDB= 1jv2 |SIZE=350|CAPTION= <scene name='initialview01'>1jv2</scene>, resolution 3.1&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1JV2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV2 OCA].
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1JV2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JV2 OCA].
==Reference==
==Reference==
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Crystal structure of the extracellular segment of integrin alpha Vbeta3., Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA, Science. 2001 Oct 12;294(5541):339-45. Epub 2001 Sep 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11546839 11546839]
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Crystal structure of the extracellular segment of integrin alpha Vbeta3., Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA, Science. 2001 Oct 12;294(5541):339-45. Epub 2001 Sep 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11546839 11546839]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: NAG]]
[[Category: NAG]]
[[Category: a-domain]]
[[Category: a-domain]]
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[[Category: admidas]]
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[[Category: admida]]
[[Category: beta-tail domain]]
[[Category: beta-tail domain]]
[[Category: cage motif]]
[[Category: cage motif]]
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[[Category: genu]]
[[Category: genu]]
[[Category: hybrid domain]]
[[Category: hybrid domain]]
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[[Category: midas]]
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[[Category: mida]]
[[Category: propeller]]
[[Category: propeller]]
[[Category: psi domain]]
[[Category: psi domain]]
[[Category: thigh domain]]
[[Category: thigh domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:27:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:08:53 2008''

Revision as of 10:08, 20 March 2008

Image:1jv2.gif


PDB ID 1jv2

Drag the structure with the mouse to rotate
, resolution 3.1Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3


Contents

Overview

Integrins are alphabeta heterodimeric receptors that mediate divalent cation-dependent cell-cell and cell-matrix adhesion through tightly regulated interactions with ligands. We have solved the crystal structure of the extracellular portion of integrin alphaVbeta3 at 3.1 A resolution. Its 12 domains assemble into an ovoid "head" and two "tails." In the crystal, alphaVbeta3 is severely bent at a defined region in its tails, reflecting an unusual flexibility that may be linked to integrin regulation. The main inter-subunit interface lies within the head, between a seven-bladed beta-propeller from alphaV and an A domain from beta3, and bears a striking resemblance to the Galpha/Gbeta interface in G proteins. A metal ion-dependent adhesion site (MIDAS) in the betaA domain is positioned to participate in a ligand-binding interface formed of loops from the propeller and betaA domains. MIDAS lies adjacent to a calcium-binding site with a potential regulatory function.

Disease

Known disease associated with this structure: Glanzmann thrombasthenia, type B OMIM:[173470]

About this Structure

1JV2 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the extracellular segment of integrin alpha Vbeta3., Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA, Science. 2001 Oct 12;294(5541):339-45. Epub 2001 Sep 6. PMID:11546839

Page seeded by OCA on Thu Mar 20 12:08:53 2008

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