Fragment-Based Drug Discovery
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | == Paclitaxel in Apoptosis == | + | <s></s>== Paclitaxel in Apoptosis == |
<StructureSection load='1ysi' size='350' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1ysi]])' scene=''> | <StructureSection load='1ysi' size='350' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1ysi]])' scene=''> | ||
This represents the inhibition of the anti-apoptotic protein, Bcl-xl, by the anti-cancer drug, paclitaxel. | This represents the inhibition of the anti-apoptotic protein, Bcl-xl, by the anti-cancer drug, paclitaxel. | ||
| + | |||
| + | Shown here is the interaction between paclitaxel and the protein via <scene name='Sandbox_reserved_394/Hydrogen_bonds/3'>hydrogen bonding</scene>. | ||
| + | |||
| + | |||
| + | Shown here is the <scene name='Sandbox_reserved_394/Hydrophobic_bonding/3'>hydrophobic bonding</scene> formed between the protein (grey) and a hydrophobic portion of paclitaxel (blue). | ||
</StructureSection> | </StructureSection> | ||
Revision as of 17:45, 19 September 2012
== Paclitaxel in Apoptosis ==
| |||||||||||
