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This Shows the possibility that the high affinity aminoglycoside complexes may have the capability to acetylate a key biosynthetic intermediate of mycothiol. Mycothiol is a major reducing agent in the myobacteria. If this occurs it may participate in the regulation of cellular redox potential.
This Shows the possibility that the high affinity aminoglycoside complexes may have the capability to acetylate a key biosynthetic intermediate of mycothiol. Mycothiol is a major reducing agent in the myobacteria. If this occurs it may participate in the regulation of cellular redox potential.
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Reference:
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Vetting, M. W., et al. "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium
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tuberculosis-Complex with Coenzyme A and Tobramycin." RCSB Protien Data Base. N.p., 28 Aug.
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2002. Web. 13 July 2011. <http://www.rcsb.org/pdb/explore/explore.do?structureId=1M4D>.
</StructureSection>
</StructureSection>

Revision as of 16:21, 18 September 2012

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Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin

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Describe the PDB (ligand/protein)

This Shows the possibility that the high affinity aminoglycoside complexes may have the capability to acetylate a key biosynthetic intermediate of mycothiol. Mycothiol is a major reducing agent in the myobacteria. If this occurs it may participate in the regulation of cellular redox potential.

Reference: Vetting, M. W., et al. "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium

    tuberculosis-Complex with Coenzyme A and Tobramycin." RCSB Protien Data Base. N.p., 28 Aug. 
    2002. Web. 13 July 2011. <http://www.rcsb.org/pdb/explore/explore.do?structureId=1M4D>.

</StructureSection>

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