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Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin

Anything in this section will appear adjacent to the 3D structure and will be scrollable.

The Ligands displayed in the molecule to the right are Coenzyme A, 3'-Phosphate-Adenosine-5'-Diphosphate, and Tobramycin. Coenzyme A (CoA) is a coenzyme the synthesizes and oxidizes fatty acids. Tobramycin is an aminoglycoside antibiotic that is used to treat a broad spectrum of bacteria, particularly gram negative. CoA and PAP contain basic and neutral amino acids while Tobramycin consists of acidic and neutral amino acids.

This Shows the possibility that the high affinity aminoglycoside complexes may have the capability to acetylate a key biosynthetic intermediate of mycothiol. Mycothiol is a major reducing agent in the myobacteria. If this occurs it may participate in the regulation of cellular redox potential.

This molecule represents the secondary structures of the protein. The Alpha helices are represented in pink and the beta strands are represented in yellow. This molecule has approximately 13 alpha helices and approximetly 18 beta strands. Molecule:

<Vetting, M. W., et al. "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin." RCSB Protien DataBase. N.p., 28 Aug.2002. Web. 13 July 2011. <http://www.rcsb.org/pdb/explore/explore.do?structureId=1M4D>.> Wikipedia. N.p., n.d. Web. 16 Sept. 2012. <http://en.wikipedia.org/wiki/Coenzyme_A>. </StructureSection>

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 Anything in this section will appear adjacent to the 3D structure and will be scrollable.
-*The Ligands displayed in the molecule to the right are Coenzyme A, 3'-Phosphate-Adenosine-5'-Diphosphate, and Tobramycin. Coenzyme A (CoA) is a coenzyme the synthesizes and oxidizes fatty acids. Tobramycin is an aminoglycoside antibiotic that is used to treat a broad spectrum of bacteria, particularly gram negative.
+*The Ligands displayed in the molecule to the right are Coenzyme A, 3'-Phosphate-Adenosine-5'-Diphosphate, and Tobramycin. Coenzyme A (CoA) is a coenzyme the synthesizes and oxidizes fatty acids. Tobramycin is an aminoglycoside antibiotic that is used to treat a broad spectrum of bacteria, particularly gram negative. CoA and PAP contain basic and neutral amino acids while Tobramycin consists of acidic and neutral amino acids.
 *This Shows the possibility that the high affinity aminoglycoside complexes  may have the capability to acetylate a key biosynthetic intermediate of mycothiol. Mycothiol is a major reducing agent in the myobacteria. If this occurs it may participate in the regulation of cellular redox potential.