1jwc
From Proteopedia
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| - | [[Image:1jwc.gif|left|200px]] | + | [[Image:1jwc.gif|left|200px]] |
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| - | '''NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN''' | + | {{Structure |
| + | |PDB= 1jwc |SIZE=350|CAPTION= <scene name='initialview01'>1jwc</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JWC is a [ | + | 1JWC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWC OCA]. |
==Reference== | ==Reference== | ||
| - | NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein., DeJong ES, Marzluff WF, Nikonowicz EP, RNA. 2002 Jan;8(1):83-96. PMID:[http:// | + | NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein., DeJong ES, Marzluff WF, Nikonowicz EP, RNA. 2002 Jan;8(1):83-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11871662 11871662] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Dejong, E S.]] | [[Category: Dejong, E S.]] | ||
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[[Category: tetraloop]] | [[Category: tetraloop]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:09:20 2008'' |
Revision as of 10:09, 20 March 2008
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NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN
Overview
The 3' end of replication-dependent histone mRNAs terminate in a conserved sequence containing a stem-loop. This 26-nt sequence is the binding site for a protein, stem-loop binding protein (SLBP), that is involved in multiple aspects of histone mRNA metabolism and regulation. We have determined the structure of the 26-nt sequence by multidimensional NMR spectroscopy. There is a 16-nt stem-loop motif, with a conserved 6-bp stem and a 4-nt loop. The loop is closed by a conserved U.A base pair that terminates the canonical A-form stem. The pyrimidine-rich 4-nt loop, UUUC, is well organized with the three uridines stacking on the helix, and the fourth base extending across the major groove into the solvent. The flanking nucleotides at the base of the hairpin stem do not assume a unique conformation, despite the fact that the 5' flanking nucleotides are a critical component of the SLBP binding site.
About this Structure
1JWC is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein., DeJong ES, Marzluff WF, Nikonowicz EP, RNA. 2002 Jan;8(1):83-96. PMID:11871662
Page seeded by OCA on Thu Mar 20 12:09:20 2008
