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4bae

From Proteopedia

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m (Protected "4bae" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bae| PDB=4bae | SCENE= }}
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===Optimisation of pyrroleamides as mycobacterial GyrB ATPase inhibitors: Structure Activity Relationship and in vivo efficacy in the mouse model of tuberculosis===
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{{ABSTRACT_PUBMED_24126580}}
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The entry 4bae is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/GYRB_MYCSM GYRB_MYCSM]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
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Authors: READ, J.A., GINGELL, H.G., Madhavapeddi, P.
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==About this Structure==
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[[4bae]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAE OCA].
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Description: Optimisation of pyrroleamides as mycobacterial GyrB ATPase inhibitors: Structure Activity Relationship and in vivo efficacy in the mouse model of tuberculosis
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==Reference==
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<ref group="xtra">PMID:024126580</ref><references group="xtra"/><references/>
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[[Category: Mycobacterium smegmatis]]
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[[Category: Gingell, H G.]]
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[[Category: Madhavapeddi, P.]]
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[[Category: Read, J A.]]
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[[Category: Dna topoisomerase]]
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[[Category: Inhibitor]]
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[[Category: Isomerase]]

Revision as of 09:41, 30 October 2013

Template:STRUCTURE 4bae

Contents

Optimisation of pyrroleamides as mycobacterial GyrB ATPase inhibitors: Structure Activity Relationship and in vivo efficacy in the mouse model of tuberculosis

Template:ABSTRACT PUBMED 24126580

Function

[GYRB_MYCSM] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.

About this Structure

4bae is a 4 chain structure with sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.

Reference

  • Hameed SP, Solapure S, Mukherjee K, Nandi V, Waterson D, Shandil R, Balganesh M, Sambandamurthy VK, Raichurkar AK, Deshpande A, Ghosh A, Awasthy D, Shanbhag G, Sheikh G, McMiken H, Puttur J, Reddy J, Werngren J, Read J, Kumar M, R M, Chinnapattu M, Madhavapeddi P, Manjrekar P, Basu R, Gaonkar S, Sharma S, Hoffner S, Humnabadkar V, Subbulakshmi V, Panduga V. Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: Structure Activity Relationship and in vivo efficacy in the mouse model of tuberculosis. Antimicrob Agents Chemother. 2013 Oct 14. PMID:24126580 doi:http://dx.doi.org/10.1128/AAC.01751-13

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