1k1s

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[[Image:1k1s.gif|left|200px]]<br /><applet load="1k1s" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1k1s.gif|left|200px]]
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caption="1k1s, resolution 2.80&Aring;" />
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'''Crystal Structure of DinB from Sulfolobus solfataricus'''<br />
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{{Structure
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|PDB= 1k1s |SIZE=350|CAPTION= <scene name='initialview01'>1k1s</scene>, resolution 2.80&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= DINB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])
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}}
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'''Crystal Structure of DinB from Sulfolobus solfataricus'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1K1S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K1S OCA].
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1K1S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K1S OCA].
==Reference==
==Reference==
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Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus., Silvian LF, Toth EA, Pham P, Goodman MF, Ellenberger T, Nat Struct Biol. 2001 Nov;8(11):984-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11685247 11685247]
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Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus., Silvian LF, Toth EA, Pham P, Goodman MF, Ellenberger T, Nat Struct Biol. 2001 Nov;8(11):984-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11685247 11685247]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Sulfolobus solfataricus]]
[[Category: Sulfolobus solfataricus]]
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[[Category: mixed a/b structure]]
[[Category: mixed a/b structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:29:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:11:22 2008''

Revision as of 10:11, 20 March 2008

Image:1k1s.gif


PDB ID 1k1s

Drag the structure with the mouse to rotate
, resolution 2.80Å
Gene: DINB (Sulfolobus solfataricus)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of DinB from Sulfolobus solfataricus


Overview

A new group of error-prone DNA polymerases overcomes the blockage posed to normal DNA replication by damaged template bases, suggesting an active site with a loose, flexible pocket that accommodates aberrant DNA structures. We have determined a 2.8 A resolution crystal structure of the Sulfolobus solfataricus Dbh protein, a DNA translesion polymerase closely related to Escherichia coli DNA polymerase IV and human polymerase kappa. A high error rate is observed for the Dbh polymerase in a range of 10(-2)-10(-3) for all 12 base substitution mispairs. The crystal structure of Dbh reveals an overall architecture resembling other DNA polymerases but has unique features that are likely to contribute to error-prone synthesis, including -1 frameshifting mutations.

About this Structure

1K1S is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus., Silvian LF, Toth EA, Pham P, Goodman MF, Ellenberger T, Nat Struct Biol. 2001 Nov;8(11):984-9. PMID:11685247

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