Sandbox reserved 392
From Proteopedia
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*The <scene name='Sandbox_reserved_392/Ligands/1'>ligands</scene> displayed in the molecule to the right are Coenzyme A and 3'-Phosphate-Adenosine-5'-Diphosphate. <scene name='Sandbox_reserved_392/Coa/1'>Coenzyme A</scene> (CoA) is a coenzyme that synthesizes and oxidizes fatty acids. <scene name='Sandbox_reserved_392/Pap/1'>PAP's</scene> IUPAC name is [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methylphosphono hydrogen phosphate. | *The <scene name='Sandbox_reserved_392/Ligands/1'>ligands</scene> displayed in the molecule to the right are Coenzyme A and 3'-Phosphate-Adenosine-5'-Diphosphate. <scene name='Sandbox_reserved_392/Coa/1'>Coenzyme A</scene> (CoA) is a coenzyme that synthesizes and oxidizes fatty acids. <scene name='Sandbox_reserved_392/Pap/1'>PAP's</scene> IUPAC name is [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methylphosphono hydrogen phosphate. | ||
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| + | * Tobramycin is an antibiotic part of the aminoglycoside family. It was derived from Streptomyces tenebrarius. Tobramycin is targets a variety of bacteria particularly gram(-) species. Some of the more common side effects are ototoxicity and nephrotoxicity. Ototoxic meaning hearing loss and nephrotoxic meaning kidney damage. The kidney damage is due to Tobramycin reabsorption through the renal tubules. Tobramycin trade name is Tobrex. It is a pregnancy category D, making it not the best choice for patients who are pregnant. Tobramycin can be given intravenously, intramuscularly, as an inhalation or ophthalmicly. The chemical formula for Tobramycin is C18H37N5O9 and the molecular mass is 467.515 g/mol. | ||
*In the study "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin" researchers studied the possibility that the high affinity aminoglycoside complex may have the capability to acetylate a key biosynthetic intermediate of mycothiol. Mycothiol is a major reducing agent in the myobacteria. If this occurs it may participate in the regulation of cellular redox potential. A redox reaction or reduction-oxidation reactions are chemical reactions that changes the oxidation atom of the atom. An example of this would be the oxidation of a carbon atom to CO2. Oxidation is the loss of electrons or a gain oxidation state of the atom or molecule. A reduction is the gain of electrons or the decrease in oxidation state. | *In the study "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin" researchers studied the possibility that the high affinity aminoglycoside complex may have the capability to acetylate a key biosynthetic intermediate of mycothiol. Mycothiol is a major reducing agent in the myobacteria. If this occurs it may participate in the regulation of cellular redox potential. A redox reaction or reduction-oxidation reactions are chemical reactions that changes the oxidation atom of the atom. An example of this would be the oxidation of a carbon atom to CO2. Oxidation is the loss of electrons or a gain oxidation state of the atom or molecule. A reduction is the gain of electrons or the decrease in oxidation state. | ||
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Wikipedia. N.p., n.d. Web. 16 Sept. 2012. <http://en.wikipedia.org/wiki/Coenzyme_A>. | Wikipedia. N.p., n.d. Web. 16 Sept. 2012. <http://en.wikipedia.org/wiki/Coenzyme_A>. | ||
Wikipedia. N.p., n.d. Web. 23 Sept. 2012. <http://en.wikipedia.org/wiki/Redox> | Wikipedia. N.p., n.d. Web. 23 Sept. 2012. <http://en.wikipedia.org/wiki/Redox> | ||
| + | Wikipedia. N.p., n.d. Web. 23 Sept. 2012. <http://en.wikipedia.org/wiki/Tobramycin> | ||
</StructureSection> | </StructureSection> | ||
Revision as of 21:01, 23 September 2012
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Possible Acetylation of Tobramycin CoA Complex by Mycobacterium Tuberculosis
- The displayed in the molecule to the right are Coenzyme A and 3'-Phosphate-Adenosine-5'-Diphosphate. (CoA) is a coenzyme that synthesizes and oxidizes fatty acids. IUPAC name is [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methylphosphono hydrogen phosphate.
- Tobramycin is an antibiotic part of the aminoglycoside family. It was derived from Streptomyces tenebrarius. Tobramycin is targets a variety of bacteria particularly gram(-) species. Some of the more common side effects are ototoxicity and nephrotoxicity. Ototoxic meaning hearing loss and nephrotoxic meaning kidney damage. The kidney damage is due to Tobramycin reabsorption through the renal tubules. Tobramycin trade name is Tobrex. It is a pregnancy category D, making it not the best choice for patients who are pregnant. Tobramycin can be given intravenously, intramuscularly, as an inhalation or ophthalmicly. The chemical formula for Tobramycin is C18H37N5O9 and the molecular mass is 467.515 g/mol.
- In the study "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin" researchers studied the possibility that the high affinity aminoglycoside complex may have the capability to acetylate a key biosynthetic intermediate of mycothiol. Mycothiol is a major reducing agent in the myobacteria. If this occurs it may participate in the regulation of cellular redox potential. A redox reaction or reduction-oxidation reactions are chemical reactions that changes the oxidation atom of the atom. An example of this would be the oxidation of a carbon atom to CO2. Oxidation is the loss of electrons or a gain oxidation state of the atom or molecule. A reduction is the gain of electrons or the decrease in oxidation state.
- This molecule represents the . The alpha helices are represented with pink arrows and the beta strands are represented with yellow arrows. This molecule has approximately 13 alpha helices and approximetly 18 beta strands.
- This structure focuses on the protein bond to the ligand. The red molecules represent an anionic or negatively charged interaction. The dark blue molecules emphasize the cationic or positively charged interactions. The cationic and anionic interactions are contributed to arginine, aspartic acid, or glycine amino acids. The light blue molecules represent histidine, which is a basic amino acid. Molecule:
- References:
<Vetting, M. W., et al. "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin." RCSB Protien DataBase. N.p., 28 Aug.2002. Web. 13 July 2011. <http://www.rcsb.org/pdb/explore/explore.do?structureId=1M4D>.> Wikipedia. N.p., n.d. Web. 16 Sept. 2012. <http://en.wikipedia.org/wiki/Coenzyme_A>. Wikipedia. N.p., n.d. Web. 23 Sept. 2012. <http://en.wikipedia.org/wiki/Redox> Wikipedia. N.p., n.d. Web. 23 Sept. 2012. <http://en.wikipedia.org/wiki/Tobramycin> </StructureSection>
