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Fragment-Based Drug Discovery
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| - | <s></s> | + | <s></s>Paclitaxel in Apoptosis |
<StructureSection load='1ysi' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1ysi]])' scene=''> | <StructureSection load='1ysi' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1ysi]])' scene=''> | ||
| - | This represents the binding of the anti-cancer drug, paclitaxel, to the anti-apoptotic protein, Bcl-xl. The protein includes six alpha helices and no beta sheets. | + | This represents the binding of the anti-cancer drug, paclitaxel, to the anti-apoptotic protein, Bcl-xl. The protein includes six alpha helices and no beta sheets. |
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| + | Bcl-xl is a protein that is over-expressed in many forms of cancers and is an initiator of tumor formation. There is also evidence that Bcl-xl expression may also contribute to chemo-resistance. | ||
Revision as of 02:10, 24 September 2012
Paclitaxel in Apoptosis
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