Sandbox reserved CDK2 Oxindole Inhibitor
From Proteopedia
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*The CDK2 is composed of a total of 7 alpha-helices and 6 beta-sheets. The <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Secondary_structures/1'>alpha-helices and beta-sheets</scene> can be seen here. | *The CDK2 is composed of a total of 7 alpha-helices and 6 beta-sheets. The <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Secondary_structures/1'>alpha-helices and beta-sheets</scene> can be seen here. | ||
*This presentation of the protein-ligand module shows the <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site/1'>active site</scene> in which the oxindole inhibitor interacts with CDK2. | *This presentation of the protein-ligand module shows the <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site/1'>active site</scene> in which the oxindole inhibitor interacts with CDK2. | ||
| - | *The oxindole inhibitor interacts with <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_phe80a/1'>Phe80A</scene> in a Pi-Pi, Pi-cation interaction. An interaction between the oxindole inhibitor and <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_ile10a/3'>Ile10A</scene> can be seen here in a hydrophobic interaction. Also, there are two sets of important hydrogen bonds between the oxindole inhibitor and CDK2: <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_leu_83a/1'>Leu83A</scene> and <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_asp86a/1'>Asp86A</scene>. | + | *The oxindole inhibitor interacts with <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_phe80a/1'>Phe80A</scene> in a Pi-Pi, Pi-cation interaction. An interaction between the oxindole inhibitor and <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_ile10a/3'>Ile10A</scene> can be seen here in a hydrophobic interaction. Also, there are two sets of important hydrogen bonds between the oxindole inhibitor and CDK2: <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_leu_83a/1'>Leu83A</scene> and <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_asp86a/1'>Asp86A</scene>. It is with these four <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Interactions/1'>interactions</scene> that the oxindole inhibitor is able to interact with CDK2 and slow the cell cycle. |
Revision as of 20:07, 25 September 2012
Cyclin-Dependend Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor
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