Fragment-Based Drug Discovery

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
<s></s>Paclitaxel in Apoptosis
+
== Paclitaxel in Apoptosis ==
<StructureSection load='1ysi' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1ysi]])' scene=''>
<StructureSection load='1ysi' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1ysi]])' scene=''>
This represents the binding of the anti-cancer drug, paclitaxel, to the anti-apoptotic protein, Bcl-xl. The protein includes seven <scene name='Sandbox_reserved_394/Alpha_helices/1'>alpha helices</scene> and no beta sheets.
This represents the binding of the anti-cancer drug, paclitaxel, to the anti-apoptotic protein, Bcl-xl. The protein includes seven <scene name='Sandbox_reserved_394/Alpha_helices/1'>alpha helices</scene> and no beta sheets.
-
Bcl-xl is a protein that is over-expressed in many forms of cancers and is an initiator of tumor formation. There is also evidence that Bcl-xl expression may also contribute to chemo-resistance. Paclitaxel has been show to effectively inhibit the over-expression of this protein thereby inducing tumor regression and increasing chemo-sensitivity.
+
Bcl-xl is a protein that is over-expressed in many forms of cancers and is an initiator of tumor formation.<ref>Oltersdorf T., Elmore S.W., Shoemaker A.R. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Vol 435|2 June 2005|doi:10.1038/nature03579</ref> There is also evidence that Bcl-xl expression may also contribute to chemo-resistance. Paclitaxel has been show to effectively inhibit the over-expression of this protein thereby inducing tumor regression and increasing chemo-sensitivity.
Line 24: Line 24:
| align="center" | <scene name='Sandbox_reserved_394/Phe109_and_ala108/1'>Ala108</scene> || align="center" | <scene name='Sandbox_reserved_394/Tyrosine_105/1'>Tyr105</scene> || align="center" | <scene name='Sandbox_reserved_394/Phe_101/1'>Phe101</scene> || align="center" | <scene name='Sandbox_reserved_394/Glycine_142/1'>Gly142</scene>
| align="center" | <scene name='Sandbox_reserved_394/Phe109_and_ala108/1'>Ala108</scene> || align="center" | <scene name='Sandbox_reserved_394/Tyrosine_105/1'>Tyr105</scene> || align="center" | <scene name='Sandbox_reserved_394/Phe_101/1'>Phe101</scene> || align="center" | <scene name='Sandbox_reserved_394/Glycine_142/1'>Gly142</scene>
|}
|}
 +
 +
</StructureSection>
</StructureSection>
 +
== References ==
 +
{{Reflist}}

Revision as of 18:36, 26 September 2012

Paclitaxel in Apoptosis

Structure of HMG-CoA reductase (PDB entry 1ysi)

Drag the structure with the mouse to rotate

References

  1. ↑ Oltersdorf T., Elmore S.W., Shoemaker A.R. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Vol 435|2 June 2005|doi:10.1038/nature03579

Proteopedia Page Contributors and Editors (what is this?)

Justin Weekley, Arthur Cox, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Fragment-Based_Drug_Discovery"
Personal tools