User:Josie N. Harmon/Sandbox 1
From Proteopedia
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<Structure load='3NS1' size='500' frame='true' align='right' caption='Crystal structure of Bovine Xanthine Oxidase in Complex with 6-Mercaptopurine' scene='Insert optional scene name here' /> | <Structure load='3NS1' size='500' frame='true' align='right' caption='Crystal structure of Bovine Xanthine Oxidase in Complex with 6-Mercaptopurine' scene='Insert optional scene name here' /> | ||
| - | Xanthine oxidase is characterized as a molybdenum containing enzyme that catalyzes the hydroxylation of a sp2 hybrized carbon in a broad range of aromatic heterocycles and aldehydes. | + | Xanthine oxidase is characterized as a molybdenum containing enzyme that catalyzes the hydroxylation of a sp2 hybrized carbon in a broad range of aromatic heterocycles and aldehydes. The crystal structure of the bovine xanthine oxidase complex shown contains two active sites with varying intrinsic activity. |
6-Mercaptopurine is classified as a cytotoxic chemotherapy agent frequently used to treat acute lymphoblastic leukemia (ALL). The 6-mercaptopurine complex consists of a total of <scene name='User:Josie_N._Harmon/Sandbox_1/Mercap_ligands/1'>five different ligands</scene> encased within the xanthine oxidase protein complex. These ligands include: Flavin-Adenine Dinucleotide, <scene name='User:Josie_N._Harmon/Sandbox_1/Fes_cluster/1'>Fe2S2 clusters</scene> , Dioxothiomolybdenum (VI) ion <scene name='User:Josie_N._Harmon/Sandbox_1/Mos_mte_labeled_black/1'>(MOS)</scene>, Phosphonic acidmono-(2-amino-5,6-dimercapto- 4-oxo-3,7,8A,9,10,10A-hexahydro-4H-8-oxo- 1,3,9,10-tetraaza-anthracen-7-ylmethyl)ester <scene name='User:Josie_N._Harmon/Sandbox_1/Mos_mte_labeled_black/1'>(MTE)</scene>, and <scene name='User:Josie_N._Harmon/Sandbox_1/Pm6/1'>9H-purine-6-thiol (6-mercaptopurine).</scene> | 6-Mercaptopurine is classified as a cytotoxic chemotherapy agent frequently used to treat acute lymphoblastic leukemia (ALL). The 6-mercaptopurine complex consists of a total of <scene name='User:Josie_N._Harmon/Sandbox_1/Mercap_ligands/1'>five different ligands</scene> encased within the xanthine oxidase protein complex. These ligands include: Flavin-Adenine Dinucleotide, <scene name='User:Josie_N._Harmon/Sandbox_1/Fes_cluster/1'>Fe2S2 clusters</scene> , Dioxothiomolybdenum (VI) ion <scene name='User:Josie_N._Harmon/Sandbox_1/Mos_mte_labeled_black/1'>(MOS)</scene>, Phosphonic acidmono-(2-amino-5,6-dimercapto- 4-oxo-3,7,8A,9,10,10A-hexahydro-4H-8-oxo- 1,3,9,10-tetraaza-anthracen-7-ylmethyl)ester <scene name='User:Josie_N._Harmon/Sandbox_1/Mos_mte_labeled_black/1'>(MTE)</scene>, and <scene name='User:Josie_N._Harmon/Sandbox_1/Pm6/1'>9H-purine-6-thiol (6-mercaptopurine).</scene> | ||
A <scene name='User:Josie_N._Harmon/Sandbox_1/6mercaptopurine_ligand/3'>secondary depiction</scene> of the structure is represented with purple arrows representing the alpha helix structures and gold arrows representing the beta strand structures. The <scene name='User:Josie_N._Harmon/Sandbox_1/Mercap_helix_blue/1'>helices </scene>of the protein backbone can also be noted by the blue arrows on the structure. The helix consists of various protein residues and an <scene name='User:Josie_N._Harmon/Sandbox_1/Hbond_colored/1'>H bond</scene> between two aromatic residues is shown here, with the blue structure representing phenylalanine and the green structure representing tryptophan. | A <scene name='User:Josie_N._Harmon/Sandbox_1/6mercaptopurine_ligand/3'>secondary depiction</scene> of the structure is represented with purple arrows representing the alpha helix structures and gold arrows representing the beta strand structures. The <scene name='User:Josie_N._Harmon/Sandbox_1/Mercap_helix_blue/1'>helices </scene>of the protein backbone can also be noted by the blue arrows on the structure. The helix consists of various protein residues and an <scene name='User:Josie_N._Harmon/Sandbox_1/Hbond_colored/1'>H bond</scene> between two aromatic residues is shown here, with the blue structure representing phenylalanine and the green structure representing tryptophan. | ||
Revision as of 18:45, 26 September 2012
Xanthine Oxidase in Complex with 6-Mercaptopurine
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Xanthine oxidase is characterized as a molybdenum containing enzyme that catalyzes the hydroxylation of a sp2 hybrized carbon in a broad range of aromatic heterocycles and aldehydes. The crystal structure of the bovine xanthine oxidase complex shown contains two active sites with varying intrinsic activity.
6-Mercaptopurine is classified as a cytotoxic chemotherapy agent frequently used to treat acute lymphoblastic leukemia (ALL). The 6-mercaptopurine complex consists of a total of encased within the xanthine oxidase protein complex. These ligands include: Flavin-Adenine Dinucleotide, , Dioxothiomolybdenum (VI) ion , Phosphonic acidmono-(2-amino-5,6-dimercapto- 4-oxo-3,7,8A,9,10,10A-hexahydro-4H-8-oxo- 1,3,9,10-tetraaza-anthracen-7-ylmethyl)ester , and
A of the structure is represented with purple arrows representing the alpha helix structures and gold arrows representing the beta strand structures. The of the protein backbone can also be noted by the blue arrows on the structure. The helix consists of various protein residues and an between two aromatic residues is shown here, with the blue structure representing phenylalanine and the green structure representing tryptophan.
