Sandbox reserved CDK2 Oxindole Inhibitor
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
*The representation displayed is that of cyclin-dependent kinase 2 (CDK2) interacting with an oxindole inhibitor. The ligand pictured is the <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Oxindole_inhibitor/2'>oxindole inhibitor</scene>, 4-(5-bromo-2-oxo-2h-indol-3-ylazo)- benzenesulfonamide. <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Cdk2/1'>CDK2</scene> is part of the Ser/Thr protein kinases. CDK2 is a positive regulator of the eukaryotic cell cycle progression and is a catalytic unit that helps the cell progress from the G1 phase to the S phase. <ref>[http://www.ncbi.nlm.nih.gov/gene/1017]</ref> | *The representation displayed is that of cyclin-dependent kinase 2 (CDK2) interacting with an oxindole inhibitor. The ligand pictured is the <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Oxindole_inhibitor/2'>oxindole inhibitor</scene>, 4-(5-bromo-2-oxo-2h-indol-3-ylazo)- benzenesulfonamide. <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Cdk2/1'>CDK2</scene> is part of the Ser/Thr protein kinases. CDK2 is a positive regulator of the eukaryotic cell cycle progression and is a catalytic unit that helps the cell progress from the G1 phase to the S phase. <ref>[http://www.ncbi.nlm.nih.gov/gene/1017]</ref> | ||
*In the study “The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor,” researchers studied whether using a topical oxindole inhibitor would reduce the chemotherapy-induced alopecia (CIA). Alopecia is characterized by hair loss. By inhibiting the CDK2, the cell cycle is slowed and the sensitivity to the epithelium from many cell cycle-active antitumor agents is reduced. Thus, a reduction in hair loss can be possible. <ref>PMID: 11141566</ref> | *In the study “The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor,” researchers studied whether using a topical oxindole inhibitor would reduce the chemotherapy-induced alopecia (CIA). Alopecia is characterized by hair loss. By inhibiting the CDK2, the cell cycle is slowed and the sensitivity to the epithelium from many cell cycle-active antitumor agents is reduced. Thus, a reduction in hair loss can be possible. <ref>PMID: 11141566</ref> | ||
| - | *The | + | *The CDK2 is composed of a total of <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Secondary_structures/1'>7 alpha-helices and 6 beta-sheets</scene>. |
| - | + | *The oxindole inhibitor interacts with CDK2 through a small <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Binding_pocket/1'>binding pocket</scene>, located at the <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site/1'>active site</scene>. | |
| - | + | *The oxindole inhbitor is able to interact with CDK2's active site through four important sets of <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Interactions/1'>interactions</scene>, thus slowing the cell cycle. The interactions include <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_phe80a/1'>Phe80A</scene> in a Pi-Pi, Pi-cation interaction, an interaction with <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_ile10a/3'>Ile10A</scene> in a hydrophobic interaction, and there are two sets of important hydrogen bonds: <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_leu_83a/1'>Leu83A</scene> and <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_asp86a/1'>Asp86A</scene>. | |
| - | *The oxindole | + | |
==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 20:16, 30 September 2012
Cyclin-Dependend Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor
| |||||||||||
