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4h30
From Proteopedia
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| - | + | {{STRUCTURE_4h30| PDB=4h30 | SCENE= }} | |
| + | ===Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.=== | ||
| + | {{ABSTRACT_PUBMED_23567804}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | ||
| - | + | ==About this Structure== | |
| - | + | [[4h30]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H30 OCA]. | |
| - | + | [[Category: Homo sapiens]] | |
| + | [[Category: Macrophage elastase]] | ||
| + | [[Category: Antoni, C.]] | ||
| + | [[Category: Carafa, L.]] | ||
| + | [[Category: Cassar-Lajeunesse, E.]] | ||
| + | [[Category: Dive, V.]] | ||
| + | [[Category: Nuti, E.]] | ||
| + | [[Category: Rossello, A.]] | ||
| + | [[Category: Stura, E A.]] | ||
| + | [[Category: Vera, L.]] | ||
| + | [[Category: Carboxylic twin inhibitor]] | ||
| + | [[Category: Dimerisation]] | ||
| + | [[Category: Divalent inhibitor]] | ||
| + | [[Category: Hydrolase-hydrolase inhibtior complex]] | ||
| + | [[Category: Metzincin]] | ||
| + | [[Category: Zinc protease]] | ||
Revision as of 11:28, 24 April 2013
Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.
Template:ABSTRACT PUBMED 23567804
Function
[MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
About this Structure
4h30 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
