1k66
From Proteopedia
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| - | [[Image:1k66.jpg|left|200px]] | + | [[Image:1k66.jpg|left|200px]] |
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| - | '''Crystal Structure of the Cyanobacterial Phytochrome Response Regulator, RcpB''' | + | {{Structure |
| + | |PDB= 1k66 |SIZE=350|CAPTION= <scene name='initialview01'>1k66</scene>, resolution 1.75Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= AF309560 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1188 Tolypothrix sp. PCC 7601]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of the Cyanobacterial Phytochrome Response Regulator, RcpB''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K66 is a [ | + | 1K66 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tolypothrix_sp._pcc_7601 Tolypothrix sp. pcc 7601]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K66 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structures of two cyanobacterial response regulators in apo- and phosphorylated form reveal a novel dimerization motif of phytochrome-associated response regulators., Benda C, Scheufler C, Tandeau de Marsac N, Gartner W, Biophys J. 2004 Jul;87(1):476-87. PMID:[http:// | + | Crystal structures of two cyanobacterial response regulators in apo- and phosphorylated form reveal a novel dimerization motif of phytochrome-associated response regulators., Benda C, Scheufler C, Tandeau de Marsac N, Gartner W, Biophys J. 2004 Jul;87(1):476-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15240481 15240481] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Tolypothrix sp. pcc 7601]] | [[Category: Tolypothrix sp. pcc 7601]] | ||
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[[Category: response regulator]] | [[Category: response regulator]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:13:08 2008'' |
Revision as of 10:13, 20 March 2008
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| , resolution 1.75Å | |||||||
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| Ligands: | |||||||
| Gene: | AF309560 (Tolypothrix sp. PCC 7601) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Cyanobacterial Phytochrome Response Regulator, RcpB
Overview
The structures of two response regulators (RRs) from the cyanobacterium Calothrix PCC7601, RcpA and RcpB, were solved to 1.9- and 1.75-A resolution, respectively. RcpA was found in phosphorylated and RcpB in nonphosphorylated form. Both RRs are members of phytochrome-associated, light-sensing two-component signal transduction pathways, based on histidine kinase-mediated receptor autophosphorylation and phosphorelay to a RR. Despite the overall folding similarity to CheY-type RRs ((beta/alpha)(5)-motif), RcpA and RcpB form homodimers, irrespective of their phosphorylation state, giving insight into a signal transduction putatively different from that of other known RRs. Dimerization is accomplished by a C-terminal extension of the RR polypeptide chain, and the surface formed by H4, beta 5, and H5, which constitute a hydrophobic contact area with distinct interactions between residues of either subunit. Sequence alignments reveal that the identified dimerization motif is archetypal for phytochrome-associated RRs, making them a novel subgroup of CheY-type RRs. The protein structures of RcpA and RcpB are compared to the recently presented protein structure of Rcp1 from Synechocystis.
About this Structure
1K66 is a Single protein structure of sequence from Tolypothrix sp. pcc 7601. Full crystallographic information is available from OCA.
Reference
Crystal structures of two cyanobacterial response regulators in apo- and phosphorylated form reveal a novel dimerization motif of phytochrome-associated response regulators., Benda C, Scheufler C, Tandeau de Marsac N, Gartner W, Biophys J. 2004 Jul;87(1):476-87. PMID:15240481
Page seeded by OCA on Thu Mar 20 12:13:08 2008
