1k85
From Proteopedia
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| - | [[Image:1k85.jpg|left|200px]] | + | [[Image:1k85.jpg|left|200px]] |
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| - | '''Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 Chitinase A1.''' | + | {{Structure |
| + | |PDB= 1k85 |SIZE=350|CAPTION= <scene name='initialview01'>1k85</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 Chitinase A1.''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K85 is a [ | + | 1K85 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K85 OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 chitinase A1., Jee JG, Ikegami T, Hashimoto M, Kawabata T, Ikeguchi M, Watanabe T, Shirakawa M, J Biol Chem. 2002 Jan 11;277(2):1388-97. Epub 2001 Oct 12. PMID:[http:// | + | Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 chitinase A1., Jee JG, Ikegami T, Hashimoto M, Kawabata T, Ikeguchi M, Watanabe T, Shirakawa M, J Biol Chem. 2002 Jan 11;277(2):1388-97. Epub 2001 Oct 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11600504 11600504] |
[[Category: Bacillus circulans]] | [[Category: Bacillus circulans]] | ||
[[Category: Chitinase]] | [[Category: Chitinase]] | ||
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[[Category: horizontal gene transfer]] | [[Category: horizontal gene transfer]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:13:47 2008'' |
Revision as of 10:13, 20 March 2008
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| Activity: | Chitinase, with EC number 3.2.1.14 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 Chitinase A1.
Overview
Growing evidence suggests that horizontal gene transfer plays an integral role in the evolution of bacterial genomes. One of the debated examples of horizontal gene transfer from animal to prokaryote is the fibronectin type III domain (FnIIID). Certain extracellular proteins of soil bacteria contain an unusual cluster of FnIIIDs, which show sequence similarity to those of animals and are likely to have been acquired horizontally from animals. Here we report the solution structure of the FnIIID of chitinase A1 from Bacillus circulans WL-12. To the best of our knowledge, this is the first tertiary structure to be reported for an FnIIID from a bacterial protein. The structure of the domain shows significant similarity to FnIIIDs from animal proteins. Sequence comparisons with FnIIIDs from other soil bacteria proteins show that the core-forming residues are highly conserved and, thus, are under strong evolutionary pressure. Striking similarities in the tertiary structures of bacterial FnIIIDs and their mammalian counterparts may support the hypothesis that the evolution of the FnIIID in bacterial carbohydrases occurred horizontally. The total lack of surface-exposed aromatic residues also suggests that the role of this FnIIID is different from those of other bacterial beta-sandwich domains, which function as carbohydrate-binding modules.
About this Structure
1K85 is a Single protein structure of sequence from Bacillus circulans. Full crystallographic information is available from OCA.
Reference
Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 chitinase A1., Jee JG, Ikegami T, Hashimoto M, Kawabata T, Ikeguchi M, Watanabe T, Shirakawa M, J Biol Chem. 2002 Jan 11;277(2):1388-97. Epub 2001 Oct 12. PMID:11600504
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