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1k83
From Proteopedia
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| - | [[Image:1k83.gif|left|200px]] | + | [[Image:1k83.gif|left|200px]] |
| - | + | ||
| - | '''Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin''' | + | {{Structure |
| + | |PDB= 1k83 |SIZE=350|CAPTION= <scene name='initialview01'>1k83</scene>, resolution 2.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=MN:MANGANESE (II) ION'>MN</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K83 is a [ | + | 1K83 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Amanita_phalloides Amanita phalloides] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1K83 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb40_1.html RNA Polymerase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K83 OCA]. |
==Reference== | ==Reference== | ||
| - | Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution., Bushnell DA, Cramer P, Kornberg RD, Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1218-22. Epub 2002 Jan 22. PMID:[http:// | + | Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution., Bushnell DA, Cramer P, Kornberg RD, Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1218-22. Epub 2002 Jan 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11805306 11805306] |
[[Category: Amanita phalloides]] | [[Category: Amanita phalloides]] | ||
[[Category: DNA-directed RNA polymerase]] | [[Category: DNA-directed RNA polymerase]] | ||
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[[Category: multiprotein complex]] | [[Category: multiprotein complex]] | ||
[[Category: transcription]] | [[Category: transcription]] | ||
| - | [[Category: zinc | + | [[Category: zinc motif]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:13:47 2008'' |
Revision as of 10:13, 20 March 2008
| |||||||
| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Activity: | DNA-directed RNA polymerase, with EC number 2.7.7.6 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin
Overview
The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.
About this Structure
1K83 is a Protein complex structure of sequences from Amanita phalloides and Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1K83 with [RNA Polymerase]. Full crystallographic information is available from OCA.
Reference
Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution., Bushnell DA, Cramer P, Kornberg RD, Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1218-22. Epub 2002 Jan 22. PMID:11805306
Page seeded by OCA on Thu Mar 20 12:13:47 2008
