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1k8i
From Proteopedia
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| - | [[Image:1k8i.jpg|left|200px]] | + | [[Image:1k8i.jpg|left|200px]] |
| - | + | ||
| - | '''CRYSTAL STRUCTURE OF MOUSE H2-DM''' | + | {{Structure |
| + | |PDB= 1k8i |SIZE=350|CAPTION= <scene name='initialview01'>1k8i</scene>, resolution 3.10Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= H2-DM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF MOUSE H2-DM''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K8I is a [ | + | 1K8I is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8I OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of mouse H2-M., Fremont DH, Crawford F, Marrack P, Hendrickson WA, Kappler J, Immunity. 1998 Sep;9(3):385-93. PMID:[http:// | + | Crystal structure of mouse H2-M., Fremont DH, Crawford F, Marrack P, Hendrickson WA, Kappler J, Immunity. 1998 Sep;9(3):385-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9768758 9768758] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: mhc]] | [[Category: mhc]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:13:56 2008'' |
Revision as of 10:14, 20 March 2008
| |||||||
| , resolution 3.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | H2-DM (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF MOUSE H2-DM
Overview
H2-M (HLA-DM in humans) resides in an acidic endosomal compartment, where it facilitates the loading of antigenic peptides into the peptide-binding groove of class II MHC. The crystal structure of a soluble form of H2-M has been solved to 3.1 A resolution, revealing a heterodimer with structural similarities to the MHC family of proteins. In contrast to its antigen-presenting cousins, the membrane distal alpha helices of H2-M pack closely together, occluding most of the binding groove except for a single large pocket near the center. The structure of H2-M has several unique features that may play a role in its function as a molecular chaperone and peptide exchange factor.
About this Structure
1K8I is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of mouse H2-M., Fremont DH, Crawford F, Marrack P, Hendrickson WA, Kappler J, Immunity. 1998 Sep;9(3):385-93. PMID:9768758
Page seeded by OCA on Thu Mar 20 12:13:56 2008
