1k8v
From Proteopedia
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| - | [[Image:1k8v.jpg|left|200px]] | + | [[Image:1k8v.jpg|left|200px]] |
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| - | '''The NMR-derived Conformation of Neuropeptide F from Moniezia expansa''' | + | {{Structure |
| + | |PDB= 1k8v |SIZE=350|CAPTION= <scene name='initialview01'>1k8v</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''The NMR-derived Conformation of Neuropeptide F from Moniezia expansa''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K8V is a [ | + | 1K8V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8V OCA]. |
==Reference== | ==Reference== | ||
| - | The NMR-derived conformation of neuropeptide F from Moniezia expansa., Miskolzie M, Kotovych G, J Biomol Struct Dyn. 2002 Jun;19(6):991-8. PMID:[http:// | + | The NMR-derived conformation of neuropeptide F from Moniezia expansa., Miskolzie M, Kotovych G, J Biomol Struct Dyn. 2002 Jun;19(6):991-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12023801 12023801] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Kotovych, G.]] | [[Category: Kotovych, G.]] | ||
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[[Category: npf]] | [[Category: npf]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:14:09 2008'' |
Revision as of 10:14, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
The NMR-derived Conformation of Neuropeptide F from Moniezia expansa
Overview
The solution structure of neuropeptide F (NPF), from the flatworm (platyhelminthes) Moniezia expansa, has been determined by (1)H NMR spectroscopy at 800 MHz in 60%/40% CD(3)OH/H(2)O. NPF is the most abundant neuropeptide in platyhelminthes. The secondary structure of NPF contains an alpha helix from residues Lys(14) to Ile(31), while the N terminus, consisting of residues Pro(-2) to Asn(13), and the C-terminus, consisting of residues Gly(32) to Phe(36), are in a random conformation. The structure was calculated by a simulated annealing protocol, and the conformational data are compared to the porcine neuropeptide Y (NPY), a peptide hormone and neurotransmitter. The exact function of NPF is unknown, but structural similarity with porcine NPY indicates that its mode of action is similar. These structural data can serve as a starting point in the design of new antiparasitic drugs.
About this Structure
1K8V is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
The NMR-derived conformation of neuropeptide F from Moniezia expansa., Miskolzie M, Kotovych G, J Biomol Struct Dyn. 2002 Jun;19(6):991-8. PMID:12023801
Page seeded by OCA on Thu Mar 20 12:14:09 2008
