Sandbox reserved CDK2 Oxindole Inhibitor
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
*In the study “The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor,” researchers studied whether using a topical oxindole inhibitor would reduce the chemotherapy-induced alopecia (CIA). Alopecia is characterized by hair loss. By inhibiting the CDK2, the cell cycle is slowed and the sensitivity to the epithelium from many cell cycle-active antitumor agents is reduced. Thus, a reduction in hair loss can be possible. <ref>PMID: 11141566</ref> | *In the study “The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor,” researchers studied whether using a topical oxindole inhibitor would reduce the chemotherapy-induced alopecia (CIA). Alopecia is characterized by hair loss. By inhibiting the CDK2, the cell cycle is slowed and the sensitivity to the epithelium from many cell cycle-active antitumor agents is reduced. Thus, a reduction in hair loss can be possible. <ref>PMID: 11141566</ref> | ||
*The CDK2 is composed of a total of <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Secondary_structures/1'>7 alpha-helices and 6 beta-sheets</scene>. | *The CDK2 is composed of a total of <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Secondary_structures/1'>7 alpha-helices and 6 beta-sheets</scene>. | ||
| - | *The oxindole inhibitor interacts with CDK2 through a small <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Binding_pocket/1'>binding pocket</scene> | + | *The oxindole inhibitor interacts with CDK2 through a small <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Binding_pocket/1'>binding pocket</scene> located at the <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site/1'>active site</scene>. |
*The oxindole inhbitor is able to interact with CDK2's active site through four important sets of <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Interactions/1'>interactions</scene>, thus slowing the cell cycle. The interactions include <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_phe80a/1'>Phe80A</scene> in a Pi-Pi, Pi-cation interaction, an interaction with <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_ile10a/3'>Ile10A</scene> in a hydrophobic interaction, and there are two sets of important hydrogen bonds: <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_leu_83a/1'>Leu83A</scene> and <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_asp86a/1'>Asp86A</scene>. | *The oxindole inhbitor is able to interact with CDK2's active site through four important sets of <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Interactions/1'>interactions</scene>, thus slowing the cell cycle. The interactions include <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_phe80a/1'>Phe80A</scene> in a Pi-Pi, Pi-cation interaction, an interaction with <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_ile10a/3'>Ile10A</scene> in a hydrophobic interaction, and there are two sets of important hydrogen bonds: <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_leu_83a/1'>Leu83A</scene> and <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site_asp86a/1'>Asp86A</scene>. | ||
==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 20:19, 30 September 2012
Cyclin-Dependend Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor
| |||||||||||
