This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Fragment-Based Drug Discovery
From Proteopedia
(Difference between revisions)
| Line 12: | Line 12: | ||
<scene name='Sandbox_reserved_394/Bcl-xl/1'>Bcl-xl</scene> is a member of the Bcl-2 family. The protein includes seven <scene name='Sandbox_reserved_394/Alpha_helices/1'>alpha helices</scene> and no beta sheets. | <scene name='Sandbox_reserved_394/Bcl-xl/1'>Bcl-xl</scene> is a member of the Bcl-2 family. The protein includes seven <scene name='Sandbox_reserved_394/Alpha_helices/1'>alpha helices</scene> and no beta sheets. | ||
| + | |||
| + | ==== Bcl-xl Inhibition ==== | ||
Inhibition of the over-expression of this protein has been shown to be effective at inducing tumor regression and increasing chemo-sensitivity. This represents the binding of an <scene name='Sandbox_reserved_394/Paclitaxel/1'>acyl-sulfonamide</scene> to the anti-apoptotic protein, . | Inhibition of the over-expression of this protein has been shown to be effective at inducing tumor regression and increasing chemo-sensitivity. This represents the binding of an <scene name='Sandbox_reserved_394/Paclitaxel/1'>acyl-sulfonamide</scene> to the anti-apoptotic protein, . | ||
Revision as of 01:16, 3 October 2012
Apoptosis by Inhibition of Bcl-2 Family Proteins
| |||||||||||
References
- ↑ Oltersdorf T., Elmore S.W., Shoemaker A.R. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Vol 435|2 June 2005|doi:10.1038/nature03579
