4g2y

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'''Unreleased structure'''
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{{STRUCTURE_4g2y| PDB=4g2y | SCENE= }}
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===Crystal structure of PDE5A complexed with its inhibitor===
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{{ABSTRACT_PUBMED_23137303}}
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The entry 4g2y is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
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Authors: Xu,Y.C., Ren,J., Li,L., Chen,T.T.
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==About this Structure==
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[[4g2y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2Y OCA].
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Description: Crystal structure of PDE5A complexed with its inhibitor
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==Reference==
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<ref group="xtra">PMID:023137303</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Chen, T T.]]
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[[Category: Ren, J.]]
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[[Category: Xu, Y C.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Phosphodiesterase]]

Revision as of 10:12, 30 June 2013

Template:STRUCTURE 4g2y

Contents

Crystal structure of PDE5A complexed with its inhibitor

Template:ABSTRACT PUBMED 23137303

Function

[PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.

About this Structure

4g2y is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wang G, Liu Z, Chen T, Wang Z, Yang H, Zheng M, Ren J, Tian G, Yang X, Li L, Li J, Suo J, Zhang R, Jiang X, Terrett NK, Shen J, Xu Y, Jiang H. Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. J Med Chem. 2012 Dec 13;55(23):10540-50. doi: 10.1021/jm301159y. Epub 2012 Nov, 19. PMID:23137303 doi:10.1021/jm301159y

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