4gmj
From Proteopedia
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{{STRUCTURE_4gmj| PDB=4gmj | SCENE= }} | {{STRUCTURE_4gmj| PDB=4gmj | SCENE= }} | ||
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===Structure of human NOT1 MIF4G domain co-crystallized with CAF1=== | ===Structure of human NOT1 MIF4G domain co-crystallized with CAF1=== | ||
| + | {{ABSTRACT_PUBMED_22977175}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN]] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref> [[http://www.uniprot.org/uniprot/CNOT7_HUMAN CNOT7_HUMAN]] Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
[[4gmj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA]. | [[4gmj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMJ OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Izaurralde, E]] | + | [[Category: Izaurralde, E.]] |
| - | [[Category: Petit, P]] | + | [[Category: Petit, P.]] |
| - | [[Category: Weichenrieder, O]] | + | [[Category: Weichenrieder, O.]] |
| - | [[Category: Wohlbold, L]] | + | [[Category: Wohlbold, L.]] |
[[Category: Ccr4-not]] | [[Category: Ccr4-not]] | ||
[[Category: Deadenylase]] | [[Category: Deadenylase]] | ||
Revision as of 21:45, 10 April 2013
Contents |
Structure of human NOT1 MIF4G domain co-crystallized with CAF1
Template:ABSTRACT PUBMED 22977175
Function
[CNOT1_HUMAN] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.[1] [2] [CNOT7_HUMAN] Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity).
About this Structure
4gmj is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. Nucleic Acids Res. 2000 Feb 1;28(3):809-17. PMID:10637334
- ↑ Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. EMBO J. 2006 Jul 12;25(13):3089-99. Epub 2006 Jun 15. PMID:16778766 doi:7601194
