1uwh

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Revision as of 06:31, 3 October 2012

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spinqualitylabelsall models PDB ID 1uwh Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1uwh, resolution 2.95Å ()
Ligands:	,
Related:	1uwj
Structural annotation: Resources: CATH : 1Uwha02, 1Uwha01, 1Uwhb02, 1Uwhb01 InterPro : Ipr003116, Ipr000719, Ipr008271, Ipr002219, Ipr011009 Pfam : PF00069 SCOP : d1uwha_, d1uwhb_ UniProt : P15056
Functional annotation: Cellular component: plasma membrane cytoplasm Biological process: protein amino acid phosphorylation anti-apoptosis signal transduction organ morphogenesis intracellular signaling cascade Molecular function: ATP binding protein binding metal ion binding protein serine/threonine kinase activity nucleotide binding zinc ion binding receptor signaling protein activity kinase activity transferase activity diacylglycerol binding protein kinase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

The complex of wild type B-RAF and BAY439006

Template:ABSTRACT PUBMED 15035987

About this Structure

1uwh is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell. 2004 Mar 19;116(6):855-67. PMID:15035987