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2lui

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'''Unreleased structure'''
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{{STRUCTURE_2lui| PDB=2lui | SCENE= }}
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===Structure of the PICK PDZ domain in complex with the DAT C-terminal===
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The entry 2lui is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>
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Authors: Erlendsson, S., Teilum, K.
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==About this Structure==
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[[2lui]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUI OCA].
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Description: Chemical Shift Assignments for the PICK1 PDZ domain fused to the C10 DAT ligand
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
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[[Category: Erlendsson, S.]]
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[[Category: Gether, U.]]
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[[Category: Heidarsson, P O.]]
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[[Category: Madsen, K L.]]
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[[Category: Poulsen, F M.]]
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[[Category: Rathje, M.]]
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[[Category: Teilum, K.]]
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[[Category: Dat c-terminal]]
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[[Category: Pdz]]
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[[Category: Pick1]]
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[[Category: Protein binding]]

Revision as of 07:16, 20 June 2013

Template:STRUCTURE 2lui

Contents

Structure of the PICK PDZ domain in complex with the DAT C-terminal

Function

[PICK1_RAT] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.[1]

About this Structure

2lui is a 1 chain structure with sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

  1. ↑ Hanley JG, Henley JM. PICK1 is a calcium-sensor for NMDA-induced AMPA receptor trafficking. EMBO J. 2005 Sep 21;24(18):3266-78. Epub 2005 Sep 1. PMID:16138078 doi:10.1038/sj.emboj.7600801

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OCA

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