4gfb

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'''Unreleased structure'''
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{{STRUCTURE_4gfb| PDB=4gfb | SCENE= }}
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===Rap1/DNA complex===
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{{ABSTRACT_PUBMED_23519416}}
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The entry 4gfb is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/RAP1_YEAST RAP1_YEAST]] Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene.
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Authors: Le Bihan, Y.-V., Matot, B., Le Du, M.-H.
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==About this Structure==
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[[4gfb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFB OCA].
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Description: Rap1/DNA complex
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==Reference==
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<ref group="xtra">PMID:022139930</ref><references group="xtra"/><references/>
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Bihan, Y V.Le.]]
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[[Category: Du, M H.Le.]]
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[[Category: Matot, B.]]
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[[Category: Double-myb]]
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[[Category: Transcription-dna complex]]

Revision as of 22:43, 10 April 2013

Template:STRUCTURE 4gfb

Contents

Rap1/DNA complex

Template:ABSTRACT PUBMED 23519416

Function

[RAP1_YEAST] Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene.

About this Structure

4gfb is a 3 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  • Matot B, Le Bihan YV, Lescasse R, Perez J, Miron S, David G, Castaing B, Weber P, Raynal B, Zinn-Justin S, Gasparini S, Le Du MH. The orientation of the C-terminal domain of the Saccharomyces cerevisiae Rap1 protein is determined by its binding to DNA. Nucleic Acids Res. 2011 Dec 1. PMID:22139930 doi:10.1093/nar/gkr1166

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