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4gxl

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4gxl| PDB=4gxl | SCENE= }}
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===The crystal structure of Galectin-8 C-CRD in complex with NDP52===
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{{ABSTRACT_PUBMED_23386746}}
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The entry 4gxl is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/LEG8_HUMAN LEG8_HUMAN]] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.<ref>PMID:21288902</ref> [[http://www.uniprot.org/uniprot/CACO2_HUMAN CACO2_HUMAN]] May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion.<ref>PMID:17635994</ref>
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Authors: Li, S., Wandel, M.P., Li, F., Liu, Z., He, C., Wu, J., Shi, Y., Randow, F.
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==About this Structure==
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[[4gxl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXL OCA].
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Description: The crystal structure of Galectin-8 C-CRD in complex with NDP52
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: He, C.]]
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[[Category: Li, F.]]
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[[Category: Li, S.]]
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[[Category: Liu, Z.]]
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[[Category: Randow, F.]]
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[[Category: Shi, Y.]]
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[[Category: Wandel, M P.]]
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[[Category: Wu, J.]]
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[[Category: Carbohydrate recognition]]
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[[Category: Ndp52]]
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[[Category: Protein binding]]
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[[Category: Protein-protein interaction]]

Revision as of 07:46, 8 May 2013

Template:STRUCTURE 4gxl

Contents

The crystal structure of Galectin-8 C-CRD in complex with NDP52

Template:ABSTRACT PUBMED 23386746

Function

[LEG8_HUMAN] Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.[1] [CACO2_HUMAN] May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion.[2]

About this Structure

4gxl is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Ideo H, Matsuzaka T, Nonaka T, Seko A, Yamashita K. Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. J Biol Chem. 2011 Apr 1;286(13):11346-55. Epub 2011 Feb 2. PMID:21288902 doi:10.1074/jbc.M110.195925
  2. ↑ Morriswood B, Ryzhakov G, Puri C, Arden SD, Roberts R, Dendrou C, Kendrick-Jones J, Buss F. T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion. J Cell Sci. 2007 Aug 1;120(Pt 15):2574-85. Epub 2007 Jul 17. PMID:17635994 doi:jcs.007005

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