4h84

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'''Unreleased structure'''
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{{STRUCTURE_4h84| PDB=4h84 | SCENE= }}
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===Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.===
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{{ABSTRACT_PUBMED_23567804}}
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The entry 4h84 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
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Authors: Stura, E.A., Antoni, C., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Dive, V., Rossello, A.
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==About this Structure==
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[[4h84]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H84 OCA].
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Description: Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.
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[[Category: Homo sapiens]]
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[[Category: Macrophage elastase]]
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[[Category: Antoni, C.]]
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[[Category: Cassar-Lajeunesse, E.]]
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[[Category: Dive, V.]]
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[[Category: Nuti, E.]]
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[[Category: Rossello, A.]]
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[[Category: Stura, E A.]]
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[[Category: Vera, L.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Metzincin]]
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[[Category: Selective carboxylate based mmp-12 inhibitor]]
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[[Category: Zinc protease]]

Revision as of 11:29, 24 April 2013

Template:STRUCTURE 4h84

Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.

Template:ABSTRACT PUBMED 23567804

Function

[MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

About this Structure

4h84 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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