4di2
From Proteopedia
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{{STRUCTURE_4di2| PDB=4di2 | SCENE= }} | {{STRUCTURE_4di2| PDB=4di2 | SCENE= }} | ||
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===Crystal structure of BACE1 in complex with hydroxyethylamine inhibitor 37=== | ===Crystal structure of BACE1 in complex with hydroxyethylamine inhibitor 37=== | ||
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{{ABSTRACT_PUBMED_22468684}} | {{ABSTRACT_PUBMED_22468684}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4di2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DI2 OCA]. | + | [[4di2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DI2 OCA]. |
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022468684</ref><references group="xtra"/><references/> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Long, A M.]] | [[Category: Long, A M.]] | ||
Revision as of 10:12, 19 June 2013
Contents |
Crystal structure of BACE1 in complex with hydroxyethylamine inhibitor 37
Template:ABSTRACT PUBMED 22468684
Function
[BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.[1] [2]
About this Structure
4di2 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Dineen TA, Weiss MM, Williamson T, Acton P, Babu-Khan S, Bartberger MD, Brown J, Chen K, Cheng Y, Citron M, Croghan MD, Dunn RT 2nd, Esmay J, Graceffa RF, Harried SS, Hickman D, Hitchcock SA, Horne DB, Huang H, Imbeah-Ampiah R, Judd T, Kaller MR, Kreiman CR, La DS, Li V, Lopez P, Louie S, Monenschein H, Nguyen TT, Pennington LD, San Miguel T, Sickmier EA, Vargas HM, Wahl RC, Wen PH, Whittington DA, Wood S, Xue Q, Yang BH, Patel VF, Zhong W. Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors. J Med Chem. 2012 Apr 18. PMID:22468684 doi:10.1021/jm300118s
- ↑ Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1456-60. PMID:10677483
- ↑ Okada H, Zhang W, Peterhoff C, Hwang JC, Nixon RA, Ryu SH, Kim TW. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J. 2010 Aug;24(8):2783-94. doi: 10.1096/fj.09-146357. Epub 2010 Mar 30. PMID:20354142 doi:10.1096/fj.09-146357
