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4bbq

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[[Image:4bbq.jpg|left|200px]]
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==Crystal structure of the CXXC and PHD domain of Human Lysine-specific Demethylase 2A (KDM2A)(FBXL11)==
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<StructureSection load='4bbq' size='340' side='right' caption='[[4bbq]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
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{{STRUCTURE_4bbq| PDB=4bbq | SCENE= }}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4bbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BBQ FirstGlance]. <br>
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===Crystal structure of the CXXC and PHD domain of Human Lysine-specific Demethylase 2A (KDM2A)(FBXL11)===
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bbq RCSB], [http://www.ebi.ac.uk/pdbsum/4bbq PDBsum]</span></td></tr>
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==About this Structure==
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</table>
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[[4bbq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBQ OCA].
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== Function ==
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[[Category: Allerston, C K.]]
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[[http://www.uniprot.org/uniprot/KDM2A_HUMAN KDM2A_HUMAN]] Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.<ref>PMID:16362057</ref> <ref>PMID:19001877</ref>
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[[Category: Arrowsmith, C H.]]
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== References ==
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[[Category: Ball, L.]]
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<references/>
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[[Category: Bountra, C.]]
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__TOC__
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[[Category: Chen, Y.]]
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</StructureSection>
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[[Category: Delft, F Von.]]
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[[Category: Human]]
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[[Category: Edlich, C.]]
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[[Category: Allerston, C K]]
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[[Category: Edwards, A.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Gileadi, O.]]
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[[Category: Ball, L]]
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[[Category: Krojer, T.]]
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[[Category: Bountra, C]]
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[[Category: Laue, E D.]]
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[[Category: Chen, Y]]
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[[Category: Li, B.]]
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[[Category: Delft, F Von]]
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[[Category: Watson, A A.]]
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[[Category: Edlich, C]]
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[[Category: Edwards, A]]
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[[Category: Gileadi, O]]
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[[Category: Krojer, T]]
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[[Category: Laue, E D]]
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[[Category: Li, B]]
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[[Category: Watson, A A]]
[[Category: Chromatin]]
[[Category: Chromatin]]
[[Category: Cpg island]]
[[Category: Cpg island]]

Revision as of 09:41, 25 December 2014

Crystal structure of the CXXC and PHD domain of Human Lysine-specific Demethylase 2A (KDM2A)(FBXL11)

4bbq, resolution 2.24Å

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