1kog

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[[Image:1kog.gif|left|200px]]<br /><applet load="1kog" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1kog.gif|left|200px]]
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caption="1kog, resolution 3.50&Aring;" />
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'''Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator'''<br />
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{{Structure
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|PDB= 1kog |SIZE=350|CAPTION= <scene name='initialview01'>1kog</scene>, resolution 3.50&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=TSB:5'-O-(N-(L-THREONYL)-SULFAMOYL)ADENOSINE'>TSB</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3]
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|GENE=
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}}
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'''Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1KOG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=TSB:'>TSB</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOG OCA].
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1KOG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOG OCA].
==Reference==
==Reference==
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Structural basis of translational control by Escherichia coli threonyl tRNA synthetase., Torres-Larios A, Dock-Bregeon AC, Romby P, Rees B, Sankaranarayanan R, Caillet J, Springer M, Ehresmann C, Ehresmann B, Moras D, Nat Struct Biol. 2002 May;9(5):343-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11953757 11953757]
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Structural basis of translational control by Escherichia coli threonyl tRNA synthetase., Torres-Larios A, Dock-Bregeon AC, Romby P, Rees B, Sankaranarayanan R, Caillet J, Springer M, Ehresmann C, Ehresmann B, Moras D, Nat Struct Biol. 2002 May;9(5):343-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11953757 11953757]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: ZN]]
[[Category: ZN]]
[[Category: protein-rna complex]]
[[Category: protein-rna complex]]
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[[Category: rna base triples]]
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[[Category: rna base triple]]
[[Category: rna double helix]]
[[Category: rna double helix]]
[[Category: rna stem-loop]]
[[Category: rna stem-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:36:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:20:06 2008''

Revision as of 10:20, 20 March 2008

Image:1kog.gif


PDB ID 1kog

Drag the structure with the mouse to rotate
, resolution 3.50Å
Ligands: and
Activity: Threonine--tRNA ligase, with EC number 6.1.1.3
Coordinates: save as pdb, mmCIF, xml



Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator


Overview

Escherichia coli threonyl-tRNA synthetase (ThrRS) represses the translation of its own messenger RNA by binding to an operator located upstream of the initiation codon. The crystal structure of the complex between the core of ThrRS and the essential domain of the operator shows that the mRNA uses the recognition mode of the tRNA anticodon loop to initiate binding. The final positioning of the operator, upon which the control mechanism is based, relies on a characteristic RNA motif adapted to the enzyme surface. The finding of other thrS operators that have this conserved motif leads to a generalization of this regulatory mechanism to a subset of Gram-negative bacteria.

About this Structure

1KOG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis of translational control by Escherichia coli threonyl tRNA synthetase., Torres-Larios A, Dock-Bregeon AC, Romby P, Rees B, Sankaranarayanan R, Caillet J, Springer M, Ehresmann C, Ehresmann B, Moras D, Nat Struct Biol. 2002 May;9(5):343-7. PMID:11953757

Page seeded by OCA on Thu Mar 20 12:20:06 2008

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