Growth factor receptor-bound protein
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | <StructureSection load=' | + | <StructureSection load='1tze' size='400' side='right' caption='Structure of human Grb2 SH2 domain complex with phosphotyrosyl derivative (PDB entry [[1tze]])' scene=''> |
'''Growth factor receptor-bound protein 2''' (GRB2) is an adaptor protein. It links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. | '''Growth factor receptor-bound protein 2''' (GRB2) is an adaptor protein. It links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. | ||
Revision as of 09:16, 4 November 2012
| |||||||||||
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
