2ymj

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m (Protected "2ymj" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_2ymj| PDB=2ymj | SCENE= }}
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===Solution structure of the QUA1 dimerization domain of pXqua, the Xenopus ortholog of Quaking.===
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{{ABSTRACT_PUBMED_23520467}}
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The entry 2ymj is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/QKIA_XENLA QKIA_XENLA]] RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). Essential for notochord development.<ref>PMID:9303534</ref>
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Authors: Ali, M., Broadhurst, R.W.
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==About this Structure==
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[[2ymj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YMJ OCA].
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Description: Solution structure of the QUA1 dimerization domain of pXqua, the Xenopus ortholog of Quaking.
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==Reference==
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<ref group="xtra">PMID:023520467</ref><references group="xtra"/><references/>
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[[Category: Xenopus laevis]]
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[[Category: Ali, M.]]
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[[Category: Broadhurst, R W.]]
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[[Category: Hairpin]]
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[[Category: Qki]]
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[[Category: Star protein]]
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[[Category: Translation]]

Revision as of 09:31, 30 October 2013

Template:STRUCTURE 2ymj

Contents

Solution structure of the QUA1 dimerization domain of pXqua, the Xenopus ortholog of Quaking.

Template:ABSTRACT PUBMED 23520467

Function

[QKIA_XENLA] RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). Essential for notochord development.[1]

About this Structure

2ymj is a 1 chain structure with sequence from Xenopus laevis. Full experimental information is available from OCA.

Reference

  1. ↑ Zorn AM, Krieg PA. The KH domain protein encoded by quaking functions as a dimer and is essential for notochord development in Xenopus embryos. Genes Dev. 1997 Sep 1;11(17):2176-90. PMID:9303534

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