4g0v

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'''Unreleased structure'''
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{{STRUCTURE_4g0v| PDB=4g0v | SCENE= }}
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===Human topoisomerase iibeta in complex with DNA and mitoxantrone===
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The entry 4g0v is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN]] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref>
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Authors: Wu, C.C., Li, T.K., Li, Y.C., Chan, N.L.
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==About this Structure==
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[[4g0v]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0V OCA].
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Description: Human topoisomerase iibeta in complex with DNA and mitoxantrone
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Chan, N L.]]
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[[Category: Li, T K.]]
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[[Category: Li, Y C.]]
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[[Category: Wu, C C.]]
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[[Category: Coiled-coil domain]]
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[[Category: Dna-binding and cleavage]]
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[[Category: Isomerase-dna-isomerase inhibitor complex]]
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[[Category: Nucleus]]
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[[Category: Toprim domain]]
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[[Category: Winged-helix domain]]

Revision as of 05:02, 18 July 2013

Template:STRUCTURE 4g0v

Contents

Human topoisomerase iibeta in complex with DNA and mitoxantrone

Function

[TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.[1] [2]

About this Structure

4g0v is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ West KL, Meczes EL, Thorn R, Turnbull RM, Marshall R, Austin CA. Mutagenesis of E477 or K505 in the B' domain of human topoisomerase II beta increases the requirement for magnesium ions during strand passage. Biochemistry. 2000 Feb 15;39(6):1223-33. PMID:10684600
  2. ↑ Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S. The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. Cell. 2003 Jun 27;113(7):905-17. PMID:12837248

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