4fsf
From Proteopedia
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| - | [[ | + | ==Crystal structure of Pseudomonas aeruginosa PBP3 complexed with compound 14== |
| + | <StructureSection load='4fsf' size='340' side='right' caption='[[4fsf]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FSF FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0W0:(4R,5S,8Z)-8-(2-AMINO-1,3-THIAZOL-4-YL)-1-[3-(1,5-DIHYDROXY-4-OXO-1,4-DIHYDROPYRIDIN-2-YL)-1,2-OXAZOL-5-YL]-5-FORMYL-11,11-DIMETHYL-1,7-DIOXO-4-(SULFOAMINO)-10-OXA-2,6,9-TRIAZADODEC-8-EN-12-OIC+ACID'>0W0</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ftsI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fsf RCSB], [http://www.ebi.ac.uk/pdbsum/4fsf PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described. | ||
| - | + | Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.,Mitton-Fry MJ, Arcari JT, Brown MF, Casavant JM, Finegan SM, Flanagan ME, Gao H, George DM, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Irvine R, Lall MS, Megan Lemmon M, Li C, Lin J, McCurdy SP, Mueller JP, Mullins L, Niosi M, Noe MC, Pattavina D, Penzien J, Plummer MS, Risley H, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Winton J, Young JA Bioorg Med Chem Lett. 2012 Sep 15;22(18):5989-94. Epub 2012 Jul 20. PMID:22892121<ref>PMID:22892121</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| - | + | ==See Also== | |
| - | + | *[[Penicillin-binding protein|Penicillin-binding protein]] | |
| - | == | + | == References == |
| - | [[ | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
| - | [[Category: Han, S | + | [[Category: Han, S]] |
[[Category: Penicillin binding protein]] | [[Category: Penicillin binding protein]] | ||
[[Category: Penicillin-binding protein-antibiotic complex]] | [[Category: Penicillin-binding protein-antibiotic complex]] | ||
Revision as of 16:31, 9 December 2014
Crystal structure of Pseudomonas aeruginosa PBP3 complexed with compound 14
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