4gs4
From Proteopedia
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{{STRUCTURE_4gs4| PDB=4gs4 | SCENE= }} | {{STRUCTURE_4gs4| PDB=4gs4 | SCENE= }} | ||
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===Structure of the alpha-tubulin acetyltransferase, alpha-TAT1=== | ===Structure of the alpha-tubulin acetyltransferase, alpha-TAT1=== | ||
| + | {{ABSTRACT_PUBMED_23071314}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/ATAT_HUMAN ATAT_HUMAN]] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development.<ref>PMID:20829795</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[4gs4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GS4 OCA]. | [[4gs4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GS4 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023071314</ref><references group="xtra"/><references/> | ||
[[Category: Alpha-tubulin N-acetyltransferase]] | [[Category: Alpha-tubulin N-acetyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 04:52, 28 August 2013
Contents |
Structure of the alpha-tubulin acetyltransferase, alpha-TAT1
Template:ABSTRACT PUBMED 23071314
Function
[ATAT_HUMAN] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development.[1]
About this Structure
4gs4 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R. Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and implications for tubulin-specific acetylation. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19655-60. doi:, 10.1073/pnas.1209357109. Epub 2012 Oct 15. PMID:23071314 doi:10.1073/pnas.1209357109
- ↑ Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J. MEC-17 is an alpha-tubulin acetyltransferase. Nature. 2010 Sep 9;467(7312):218-22. doi: 10.1038/nature09324. PMID:20829795 doi:10.1038/nature09324
