1kwi

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[[Image:1kwi.jpg|left|200px]]<br /><applet load="1kwi" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1kwi.jpg|left|200px]]
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caption="1kwi, resolution 2.19&Aring;" />
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'''Crystal Structure Analysis of the Cathelicidin Motif of Protegrins'''<br />
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{{Structure
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|PDB= 1kwi |SIZE=350|CAPTION= <scene name='initialview01'>1kwi</scene>, resolution 2.19&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= pg3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa])
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}}
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'''Crystal Structure Analysis of the Cathelicidin Motif of Protegrins'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1KWI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWI OCA].
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1KWI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KWI OCA].
==Reference==
==Reference==
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Structure of the cathelicidin motif of protegrin-3 precursor: structural insights into the activation mechanism of an antimicrobial protein., Sanchez JF, Hoh F, Strub MP, Aumelas A, Dumas C, Structure. 2002 Oct;10(10):1363-70. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12377122 12377122]
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Structure of the cathelicidin motif of protegrin-3 precursor: structural insights into the activation mechanism of an antimicrobial protein., Sanchez JF, Hoh F, Strub MP, Aumelas A, Dumas C, Structure. 2002 Oct;10(10):1363-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12377122 12377122]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: selenocystine]]
[[Category: selenocystine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:38:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:23:06 2008''

Revision as of 10:23, 20 March 2008

Image:1kwi.jpg


PDB ID 1kwi

Drag the structure with the mouse to rotate
, resolution 2.19Å
Gene: pg3 (Sus scrofa)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure Analysis of the Cathelicidin Motif of Protegrins


Overview

Cathelicidins are a family of antimicrobial proteins isolated from leucocytes and epithelia cells that contribute to the innate host defense mechanisms in mammalians. Located in the C-terminal part of the holoprotein, the cathelicidin-derived antimicrobial peptide is liberated by a specific protease cleavage. Here, we report the X-ray structure of the cathelicidin motif of protegrin-3 solved by MAD phasing using the selenocysteine-labeled protein. Its overall structure represents a fold homologous to the cystatin family and adopts two native states, a monomer, and a domain-swapped dimer. This crystal structure is the first example of a structural characterization of the highly conserved cathelicidin motif and thus provides insights into the possible mechanism of activation of the antimicrobial protegrin peptide.

About this Structure

1KWI is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of the cathelicidin motif of protegrin-3 precursor: structural insights into the activation mechanism of an antimicrobial protein., Sanchez JF, Hoh F, Strub MP, Aumelas A, Dumas C, Structure. 2002 Oct;10(10):1363-70. PMID:12377122

Page seeded by OCA on Thu Mar 20 12:23:06 2008

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