4e2j

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[[Image:4e2j.png|left|200px]]
 
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{{STRUCTURE_4e2j| PDB=4e2j | SCENE= }}
{{STRUCTURE_4e2j| PDB=4e2j | SCENE= }}
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===X-Ray Crystal Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with mometasone furoate and TIF-2 coactivator fragment===
===X-Ray Crystal Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with mometasone furoate and TIF-2 coactivator fragment===
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{{ABSTRACT_PUBMED_22437833}}
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{{ABSTRACT_PUBMED_22437833}}
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==Disease==
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[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
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==Function==
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[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:022437833</ref><references group="xtra"/>
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<ref group="xtra">PMID:022437833</ref><references group="xtra"/><references/>
[[Category: Synthetic construct]]
[[Category: Synthetic construct]]
[[Category: Deshpande, K.]]
[[Category: Deshpande, K.]]

Revision as of 09:11, 24 March 2013

Template:STRUCTURE 4e2j

Contents

X-Ray Crystal Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with mometasone furoate and TIF-2 coactivator fragment

Template:ABSTRACT PUBMED 22437833

Disease

[NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.

Function

[NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.[1]

About this Structure

4e2j is a 4 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA.

See Also

Reference

  • Kohn JA, Deshpande K, Ortlund EA. Deciphering Modern Glucocorticoid Cross-pharmacology Using Ancestral Corticosteroid Receptors. J Biol Chem. 2012 May 11;287(20):16267-75. Epub 2012 Mar 21. PMID:22437833 doi:10.1074/jbc.M112.346411
  1. ↑ Voegel JJ, Heine MJ, Tini M, Vivat V, Chambon P, Gronemeyer H. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 1998 Jan 15;17(2):507-19. PMID:9430642 doi:10.1093/emboj/17.2.507

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