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1cjc
From Proteopedia
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| - | [[Image:1cjc.png|left|200px]] | ||
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{{STRUCTURE_1cjc| PDB=1cjc | SCENE= }} | {{STRUCTURE_1cjc| PDB=1cjc | SCENE= }} | ||
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===STRUCTURE OF ADRENODOXIN REDUCTASE OF MITOCHONDRIAL P450 SYSTEMS=== | ===STRUCTURE OF ADRENODOXIN REDUCTASE OF MITOCHONDRIAL P450 SYSTEMS=== | ||
| + | {{ABSTRACT_PUBMED_10369776}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/ADRO_BOVIN ADRO_BOVIN]] Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:010369776</ref><ref group="xtra">PMID:017658942</ref><references group="xtra"/> | + | <ref group="xtra">PMID:010369776</ref><ref group="xtra">PMID:017658942</ref><references group="xtra"/><references/> |
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Schulz, G E.]] | [[Category: Schulz, G E.]] | ||
Revision as of 14:14, 21 March 2013
Contents |
STRUCTURE OF ADRENODOXIN REDUCTASE OF MITOCHONDRIAL P450 SYSTEMS
Template:ABSTRACT PUBMED 10369776
Function
[ADRO_BOVIN] Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
About this Structure
1cjc is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.
See Also
Reference
- Ziegler GA, Vonrhein C, Hanukoglu I, Schulz GE. The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis. J Mol Biol. 1999 Jun 18;289(4):981-90. PMID:10369776 doi:10.1006/jmbi.1999.2807
- Ojha S, Meng EC, Babbitt PC. Evolution of function in the "two dinucleotide binding domains" flavoproteins. PLoS Comput Biol. 2007 Jul;3(7):e121. PMID:17658942 doi:10.1371/journal.pcbi.0030121
