1l2h

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[[Image:1l2h.jpg|left|200px]]<br /><applet load="1l2h" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1l2h.jpg|left|200px]]
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caption="1l2h, resolution 1.54&Aring;" />
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'''Crystal structure of Interleukin 1-beta F42W/W120F mutant'''<br />
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{{Structure
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|PDB= 1l2h |SIZE=350|CAPTION= <scene name='initialview01'>1l2h</scene>, resolution 1.54&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of Interleukin 1-beta F42W/W120F mutant'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1L2H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2H OCA].
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1L2H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2H OCA].
==Reference==
==Reference==
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Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta., Rudolph MG, Kelker MS, Schneider TR, Yeates TO, Oseroff V, Heidary DK, Jennings PA, Wilson IA, Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):290-8. Epub 2003, Jan 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12554939 12554939]
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Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta., Rudolph MG, Kelker MS, Schneider TR, Yeates TO, Oseroff V, Heidary DK, Jennings PA, Wilson IA, Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):290-8. Epub 2003, Jan 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12554939 12554939]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein folding]]
[[Category: protein folding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:40:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:25:26 2008''

Revision as of 10:25, 20 March 2008

Image:1l2h.jpg


PDB ID 1l2h

Drag the structure with the mouse to rotate
, resolution 1.54Å
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Interleukin 1-beta F42W/W120F mutant


Contents

Overview

The crystal structure at 1.54 A resolution of a double mutant of interleukin-1beta (F42W/W120F), a cytokine secreted by macrophages, was determined by multiple-wavelength anomalous dispersion (MAD) using data from highly twinned selenomethionine-modified crystals. The space group is P4(3), with unit-cell parameters a = b = 53.9, c = 77.4 A. Self-rotation function analysis and various intensity statistics revealed the presence of merohedral twinning in crystals of both the native (twinning fraction alpha approximately 0.35) and SeMet (alpha approximately 0.40) forms. Structure determination and refinement are discussed with emphasis on the possible reasons for successful phasing using untreated twinned MAD data.

Disease

Known disease associated with this structure: Gastric cancer risk after H. pylori infection OMIM:[147720]

About this Structure

1L2H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta., Rudolph MG, Kelker MS, Schneider TR, Yeates TO, Oseroff V, Heidary DK, Jennings PA, Wilson IA, Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):290-8. Epub 2003, Jan 23. PMID:12554939

Page seeded by OCA on Thu Mar 20 12:25:26 2008

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