4dgw

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[[Image:4dgw.png|left|200px]]
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==Crystal Structure of the SF3a splicing factor complex of U2 snRNP==
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<StructureSection load='4dgw' size='340' side='right' caption='[[4dgw]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4dgw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DGW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dgw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dgw RCSB], [http://www.ebi.ac.uk/pdbsum/4dgw PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SF3a is an evolutionarily conserved heterotrimeric complex essential for pre-mRNA splicing. It functions in spliceosome assembly within the mature U2 snRNP (small nuclear ribonucleoprotein particle), and its displacement from the spliceosome initiates the first step of the splicing reaction. We have identified a core domain of the yeast SF3a complex required for complex assembly and determined its crystal structure. The structure shows a bifurcated assembly of three subunits, Prp9, Prp11 and Prp21, with Prp9 interacting with Prp21 via a bidentate-binding mode, and Prp21 wrapping around Prp11. Structure-guided biochemical analysis also shows that Prp9 harbours a major binding site for stem-loop IIa of U2 snRNA. These findings provide mechanistic insights into the assembly of U2 snRNP.
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{{STRUCTURE_4dgw| PDB=4dgw | SCENE= }}
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Structure and assembly of the SF3a splicing factor complex of U2 snRNP.,Lin PC, Xu RM EMBO J. 2012 Feb 7;31(6):1579-90. doi: 10.1038/emboj.2012.7. PMID:22314233<ref>PMID:22314233</ref>
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===Crystal Structure of the SF3a splicing factor complex of U2 snRNP===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22314233}}
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==About this Structure==
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[[4dgw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGW OCA].
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==See Also==
==See Also==
*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022314233</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Lin, P C.]]
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[[Category: Lin, P C]]
[[Category: Splicing]]
[[Category: Splicing]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]

Revision as of 16:52, 9 December 2014

Crystal Structure of the SF3a splicing factor complex of U2 snRNP

4dgw, resolution 3.11Å

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