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1lbd
From Proteopedia
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| - | [[Image:1lbd.gif|left|200px]] | + | [[Image:1lbd.gif|left|200px]] |
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| - | '''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA''' | + | {{Structure |
| + | |PDB= 1lbd |SIZE=350|CAPTION= <scene name='initialview01'>1lbd</scene>, resolution 2.7Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LBD is a [ | + | 1LBD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBD OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha., Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D, Nature. 1995 Jun 1;375(6530):377-82. PMID:[http:// | + | Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha., Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D, Nature. 1995 Jun 1;375(6530):377-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7760929 7760929] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: nuclear receptor]] | [[Category: nuclear receptor]] | ||
[[Category: spine]] | [[Category: spine]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:28:54 2008'' |
Revision as of 10:28, 20 March 2008
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| , resolution 2.7Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Overview
The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the homodimerization surface, and hydrophobic heptad repeats participate in stabilizing the fold. The existence of a ligand-binding pocket is proposed that would allow 9-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors.
About this Structure
1LBD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha., Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D, Nature. 1995 Jun 1;375(6530):377-82. PMID:7760929
Page seeded by OCA on Thu Mar 20 12:28:54 2008
