1lgp

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[[Image:1lgp.jpg|left|200px]]<br /><applet load="1lgp" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1lgp.jpg|left|200px]]
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caption="1lgp, resolution 2.00&Aring;" />
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'''Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein complexed with tungstate'''<br />
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{{Structure
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|PDB= 1lgp |SIZE=350|CAPTION= <scene name='initialview01'>1lgp</scene>, resolution 2.00&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein complexed with tungstate'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1LGP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=WO4:'>WO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LGP OCA].
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1LGP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LGP OCA].
==Reference==
==Reference==
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Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate., Stavridi ES, Huyen Y, Loreto IR, Scolnick DM, Halazonetis TD, Pavletich NP, Jeffrey PD, Structure. 2002 Jul;10(7):891-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12121644 12121644]
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Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate., Stavridi ES, Huyen Y, Loreto IR, Scolnick DM, Halazonetis TD, Pavletich NP, Jeffrey PD, Structure. 2002 Jul;10(7):891-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12121644 12121644]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tungstate]]
[[Category: tungstate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:44:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:30:39 2008''

Revision as of 10:30, 20 March 2008

Image:1lgp.jpg


PDB ID 1lgp

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein complexed with tungstate


Overview

The Chfr mitotic checkpoint protein is frequently inactivated in human cancer. We determined the three-dimensional structure of its FHA domain in its native form and in complex with tungstate, an analog of phosphate. The structures revealed a beta sandwich fold similar to the previously determined folds of the Rad53 N- and C-terminal FHA domains, except that the Rad53 domains were monomeric, whereas the Chfr FHA domain crystallized as a segment-swapped dimer. The ability of the Chfr FHA domain to recognize tungstate suggests that it shares the ability with other FHA domains to bind phosphoproteins. Nevertheless, differences in the sequence and structure of the Chfr and Rad53 FHA domains suggest that FHA domains can be divided into families with distinct binding properties.

About this Structure

1LGP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate., Stavridi ES, Huyen Y, Loreto IR, Scolnick DM, Halazonetis TD, Pavletich NP, Jeffrey PD, Structure. 2002 Jul;10(7):891-9. PMID:12121644

Page seeded by OCA on Thu Mar 20 12:30:39 2008

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