3pe6
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[Image:3pe6.png|left|200px]] | ||
| - | |||
{{STRUCTURE_3pe6| PDB=3pe6 | SCENE= }} | {{STRUCTURE_3pe6| PDB=3pe6 | SCENE= }} | ||
| - | |||
===Crystal Structure of a soluble form of human MGLL in complex with an inhibitor=== | ===Crystal Structure of a soluble form of human MGLL in complex with an inhibitor=== | ||
| - | |||
{{ABSTRACT_PUBMED_21308848}} | {{ABSTRACT_PUBMED_21308848}} | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/MGLL_HUMAN MGLL_HUMAN]] Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.<ref>PMID:20079333</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3pe6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PE6 OCA]. | [[3pe6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PE6 OCA]. | ||
| - | |||
| - | ==See Also== | ||
| - | *[[Lipase|Lipase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021308848</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021308848</ref><references group="xtra"/><references/> |
[[Category: Acylglycerol lipase]] | [[Category: Acylglycerol lipase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 09:03, 19 June 2013
Contents |
Crystal Structure of a soluble form of human MGLL in complex with an inhibitor
Template:ABSTRACT PUBMED 21308848
Function
[MGLL_HUMAN] Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.[1]
About this Structure
3pe6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Schalk-Hihi C, Schubert C, Alexander R, Bayoumy S, Clemente JC, Deckman I, Desjarlais RL, Dzordzorme KC, Flores CM, Grasberger B, Kranz JK, Lewandowski F, Liu L, Ma H, Maguire D, Macielag MJ, McDonnell ME, Haarlander TM, Miller R, Milligan C, Reynolds C, Kuo LC. Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 A resolution. Protein Sci. 2011 Feb 3. doi: 10.1002/pro.596. PMID:21308848 doi:10.1002/pro.596
- ↑ Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell. 2010 Jan 8;140(1):49-61. doi: 10.1016/j.cell.2009.11.027. PMID:20079333 doi:10.1016/j.cell.2009.11.027
