1wsu

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[[Image:1wsu.png|left|200px]]
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==C-terminal domain of elongation factor selB complexed with SECIS RNA==
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<StructureSection load='1wsu' size='340' side='right' caption='[[1wsu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wsu]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WSU FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">selB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1525 Moorella thermoacetica])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wsu RCSB], [http://www.ebi.ac.uk/pdbsum/1wsu PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/1wsu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In bacteria, incorporation of selenocysteine, the 21(st) amino acid, into proteins requires elongation factor SelB, which has the unusual property of binding to both transfer RNA (tRNA) and mRNA. SelB binds to an mRNA hairpin formed by the selenocysteine insertion sequence (SECIS) with extremely high specificity, the molecular basis of which has been unknown. We have determined the crystal structure of the mRNA-binding domain of SelB in complex with SECIS RNA at a resolution of 2.3 A. This is the first example of a complex between an RNA and a winged-helix (WH) domain, a motif found in many DNA-binding proteins and recently discovered in RNA-binding proteins. Notably, RNA binding does not induce a major conformational change in the WH motif. The structure reveals a new mode of RNA recognition with a geometry that allows the complex to wrap around the small ribosomal subunit.
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{{STRUCTURE_1wsu| PDB=1wsu | SCENE= }}
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Structural basis for mRNA recognition by elongation factor SelB.,Yoshizawa S, Rasubala L, Ose T, Kohda D, Fourmy D, Maenaka K Nat Struct Mol Biol. 2005 Feb;12(2):198-203. Epub 2005 Jan 23. PMID:15665870<ref>PMID:15665870</ref>
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===C-terminal domain of elongation factor selB complexed with SECIS RNA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15665870}}
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==About this Structure==
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[[1wsu]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSU OCA].
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==See Also==
==See Also==
*[[Elongation factor|Elongation factor]]
*[[Elongation factor|Elongation factor]]
*[[SelB|SelB]]
*[[SelB|SelB]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015665870</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Moorella thermoacetica]]
[[Category: Moorella thermoacetica]]
[[Category: Fourmy, D.]]
[[Category: Fourmy, D.]]

Revision as of 21:35, 28 September 2014

C-terminal domain of elongation factor selB complexed with SECIS RNA

1wsu, resolution 2.30Å

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