1lj9
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1lj9.gif|left|200px]] | + | [[Image:1lj9.gif|left|200px]] |
| - | + | ||
| - | '''The crystal structure of the transcriptional regulator SlyA''' | + | {{Structure |
| + | |PDB= 1lj9 |SIZE=350|CAPTION= <scene name='initialview01'>1lj9</scene>, resolution 1.60Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= REF02436 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis]) | ||
| + | }} | ||
| + | |||
| + | '''The crystal structure of the transcriptional regulator SlyA''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1LJ9 is a [ | + | 1LJ9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LJ9 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of Enterococcus faecalis SlyA-like transcriptional factor., Wu RY, Zhang RG, Zagnitko O, Dementieva I, Maltzev N, Watson JD, Laskowski R, Gornicki P, Joachimiak A, J Biol Chem. 2003 May 30;278(22):20240-4. Epub 2003 Mar 20. PMID:[http:// | + | Crystal structure of Enterococcus faecalis SlyA-like transcriptional factor., Wu RY, Zhang RG, Zagnitko O, Dementieva I, Maltzev N, Watson JD, Laskowski R, Gornicki P, Joachimiak A, J Biol Chem. 2003 May 30;278(22):20240-4. Epub 2003 Mar 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12649270 12649270] |
[[Category: Enterococcus faecalis]] | [[Category: Enterococcus faecalis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 20: | Line 29: | ||
[[Category: hth dna binding protein]] | [[Category: hth dna binding protein]] | ||
[[Category: mcsg]] | [[Category: mcsg]] | ||
| - | [[Category: midwest center for structural | + | [[Category: midwest center for structural genomic]] |
[[Category: protein structure initiative]] | [[Category: protein structure initiative]] | ||
[[Category: psi]] | [[Category: psi]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:31:28 2008'' |
Revision as of 10:31, 20 March 2008
| |||||||
| , resolution 1.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | REF02436 (Enterococcus faecalis) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The crystal structure of the transcriptional regulator SlyA
Overview
The crystal structure of a SlyA transcriptional regulator at 1.6 A resolution is presented, and structural relationships between members of the MarR/SlyA family are discussed. The SlyA family, which includes SlyA, Rap, Hor, and RovA proteins, is widely distributed in bacterial and archaeal genomes. Current evidence suggests that SlyA-like factors act as repressors, activators, and modulators of gene transcription. These proteins have been shown to up-regulate the expression of molecular chaperones, acid-resistance proteins, and cytolysin, and down-regulate several biosynthetic enzymes. The structure of SlyA from Enterococcus faecalis, determined as a part of an ongoing structural genomics initiative (www.mcsg.anl.gov), revealed the same winged helix DNA-binding motif that was recently found in the MarR repressor from Escherichia coli and the MexR repressor from Pseudomonas aeruginosa, a sequence homologue of MarR. Phylogenetic analysis of the MarR/SlyA family suggests that Sly is placed between the SlyA and MarR subfamilies and shows significant sequence similarity to members of both subfamilies.
About this Structure
1LJ9 is a Single protein structure of sequence from Enterococcus faecalis. Full crystallographic information is available from OCA.
Reference
Crystal structure of Enterococcus faecalis SlyA-like transcriptional factor., Wu RY, Zhang RG, Zagnitko O, Dementieva I, Maltzev N, Watson JD, Laskowski R, Gornicki P, Joachimiak A, J Biol Chem. 2003 May 30;278(22):20240-4. Epub 2003 Mar 20. PMID:12649270
Page seeded by OCA on Thu Mar 20 12:31:28 2008
