1lm5
From Proteopedia
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| - | [[Image:1lm5.jpg|left|200px]] | + | [[Image:1lm5.jpg|left|200px]] |
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| - | '''Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure''' | + | {{Structure |
| + | |PDB= 1lm5 |SIZE=350|CAPTION= <scene name='initialview01'>1lm5</scene>, resolution 1.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LM5 is a [ | + | 1LM5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LM5 OCA]. |
==Reference== | ==Reference== | ||
| - | Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure., Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI, Nat Struct Biol. 2002 Aug;9(8):612-20. PMID:[http:// | + | Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure., Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI, Nat Struct Biol. 2002 Aug;9(8):612-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12101406 12101406] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: plakin repeat]] | [[Category: plakin repeat]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:32:29 2008'' |
Revision as of 10:32, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Contents |
Overview
Desmosomes are intercellular junctions in which cadherin cell adhesion molecules are linked to the intermediate filament (IF) system. Desmoplakin is a member of the plakin family of IF-binding proteins. The C-terminal domain of desmoplakin (DPCT) mediates binding to IFs in desmosomes. The DPCT sequence contains three regions, termed A, B and C, consisting of 4.5 copies of a 38-amino acid repeat motif. We demonstrate that these regions form discrete subdomains that bind to IFs and report the crystal structures of domains B and C. In contrast to the elongated structures formed by other kinds of repeat motifs, the plakin repeats form a globular structure with a unique fold. A conserved basic groove found on the domain may represent an IF-binding site.
Disease
Known diseases associated with this structure: Arrhythmogenic right ventricular dysplasia 8 OMIM:[125647], Dilated cardiomyopathy with woolly hair and keratoderma OMIM:[125647], Epidermolysis bullosa, lethal acantholytic OMIM:[125647], Keratosis palmoplantaris striata II OMIM:[125647], Skin fragility-woolly hair syndrome OMIM:[125647]
About this Structure
1LM5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure., Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI, Nat Struct Biol. 2002 Aug;9(8):612-20. PMID:12101406
Page seeded by OCA on Thu Mar 20 12:32:29 2008
