1lpi

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[[Image:1lpi.gif|left|200px]]<br /><applet load="1lpi" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1lpi.gif|left|200px]]
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caption="1lpi, resolution 2.00&Aring;" />
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'''HEW LYSOZYME: TRP...NA CATION-PI INTERACTION'''<br />
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{{Structure
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|PDB= 1lpi |SIZE=350|CAPTION= <scene name='initialview01'>1lpi</scene>, resolution 2.00&Aring;
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|SITE= <scene name='pdbsite=PON:Binding+Site+Of+A+Na+Cation+Stabilized+By+Pi-Cation+Inte+...'>PON</scene>
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|LIGAND= <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]
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|GENE=
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}}
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'''HEW LYSOZYME: TRP...NA CATION-PI INTERACTION'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1LPI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Known structural/functional Site: <scene name='pdbsite=PON:Binding+Site+Of+A+Na+Cation+Stabilized+By+Pi-Cation+Inte+...'>PON</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPI OCA].
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1LPI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPI OCA].
==Reference==
==Reference==
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Cation-pi (Na+-Trp) interactions in the crystal structure of tetragonal lysozyme., Wouters J, Protein Sci. 1998 Nov;7(11):2472-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9828016 9828016]
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Cation-pi (Na+-Trp) interactions in the crystal structure of tetragonal lysozyme., Wouters J, Protein Sci. 1998 Nov;7(11):2472-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9828016 9828016]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Lysozyme]]
[[Category: Lysozyme]]
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[[Category: o-glycosyl]]
[[Category: o-glycosyl]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:47:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:33:37 2008''

Revision as of 10:33, 20 March 2008

Image:1lpi.gif


PDB ID 1lpi

Drag the structure with the mouse to rotate
, resolution 2.00Å
Sites:
Ligands:
Activity: Lysozyme, with EC number 3.2.1.17
Coordinates: save as pdb, mmCIF, xml



HEW LYSOZYME: TRP...NA CATION-PI INTERACTION


Overview

Experimental evidence of a cation-pi interaction between a sodium cation (Na+) and the indole ring of residue Trp123 in a structure (2.0 A) of hen egg-white lysozyme is presented. The geometry of the metal ion-pi interaction observed in the protein structure (distance between the aromatic plane and the cation approximately 4 A) is consistent with geometries observed among small molecules crystal structures and quantum chemistry ab initio calculations. The present crystal structure of lysozyme provides unique structural information about the geometry of binding of cations to pi systems in proteins. It shows that the metal ion-pi interaction within proteins is not significantly different from similar bindings found in small molecules and that it can be modeled by theoretical methods.

About this Structure

1LPI is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Cation-pi (Na+-Trp) interactions in the crystal structure of tetragonal lysozyme., Wouters J, Protein Sci. 1998 Nov;7(11):2472-5. PMID:9828016

Page seeded by OCA on Thu Mar 20 12:33:37 2008

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