2kix

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[[Image:2kix.png|left|200px]]
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==Channel domain of BM2 protein from influenza B virus==
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<StructureSection load='2kix' size='340' side='right' caption='[[2kix]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kix]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KIX FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kix OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kix RCSB], [http://www.ebi.ac.uk/pdbsum/2kix PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Influenza B virus contains an integral membrane protein, BM2, that oligomerizes in the viral membrane to form a pH-activated proton channel. Here we report the solution structures of both the membrane-embedded channel domain and the cytoplasmic domain of BM2. The channel domain assumes a left-handed coiled-coil tetramer formation with a helical packing angle of -37 degrees to form a polar pore in the membrane for conducting ions. Mutagenesis and proton flux experiments identified residues involved in proton relay and suggest a mechanism of proton conductance. The cytoplasmic domain of BM2 also forms a coiled-coil tetramer. It has a bipolar charge distribution, in which a negatively charged region interacts specifically with the M1 matrix protein that is involved in packaging the genome in the virion. This interaction suggests BM2 also recruits matrix proteins to the cell surface during virus budding, making BM2 an unusual membrane protein with the dual roles of conducting ions and recruiting proteins to the membrane.
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{{STRUCTURE_2kix| PDB=2kix | SCENE= }}
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Solution structure and functional analysis of the influenza B proton channel.,Wang J, Pielak RM, McClintock MA, Chou JJ Nat Struct Mol Biol. 2009 Dec;16(12):1267-71. Epub 2009 Nov 8. PMID:19898475<ref>PMID:19898475</ref>
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===Channel domain of BM2 protein from influenza B virus===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19898475}}
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==About this Structure==
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[[2kix]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIX OCA].
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==See Also==
==See Also==
*[[M2 protein|M2 protein]]
*[[M2 protein|M2 protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019898475</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Viruses]]
[[Category: Viruses]]
[[Category: Chou, J.]]
[[Category: Chou, J.]]

Revision as of 01:06, 2 October 2014

Channel domain of BM2 protein from influenza B virus

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